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Ppm1b Gene Detail
Summary
  • Symbol
    Ppm1b
  • Name
    protein phosphatase 1B, magnesium dependent, beta isoform
  • Synonyms
    PP2CB
  • Feature Type
    protein coding gene
  • IDs
    MGI:101841
    NCBI Gene: 19043
Location & Maps
more
  • Sequence Map
    Chr17:84956741-85023991 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      67251 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PPM1B, protein phosphatase, Mg2+/Mn2+ dependent 1B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPM1B, protein phosphatase, Mg2+/Mn2+ dependent 1B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PP2CB, PP2C-beta, PP2CBETA, PP2C-beta-X, PPC2BETAX
  • Links
    NCBI Gene ID: 5495
    neXtProt AC: NX_O75688

  • Chr Location
    2p21; chr2:44168803-44244425 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2027
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PPM1B
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in early pre-implantation lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061130 Ensembl Gene Model | MGI Sequence Detail 67251 C57BL/6J ±  kb
transcript ENSMUST00000080217 Ensembl | MGI Sequence Detail 2753 Not Applicable  
polypeptide ENSMUSP00000079107 Ensembl | MGI Sequence Detail 477 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    37 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • EC
  • InterPro Domains
    IPR000222 PPM-type phosphatase, divalent cation binding
    IPR001932 PPM-type phosphatase domain
    IPR015655 Protein phosphatase 2C family
    IPR012911 Protein serine/threonine phosphatase 2C, C-terminal
Molecular
Reagents
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  • All nucleic 28
    Genomic 2
    cDNA 26

    Microarray probesets 10
Other
Accession IDs
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MGD-MRK-18662
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:19661 Terasawa T, et al., Molecular cloning of a novel isotype of Mg(2+)-dependent protein phosphatase beta (type 2C beta) enriched in brain and heart. Arch Biochem Biophys. 1993 Dec;307(2):342-9
  • Latest
    J:195066 Tasdelen I, et al., The serine/threonine phosphatase PPM1B (PP2Cbeta) selectively modulates PPARgamma activity. Biochem J. 2013 Apr 1;451(1):45-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory