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Ppm1b Gene Detail
Summary
  • Symbol
    Ppm1b
  • Name
    protein phosphatase 1B, magnesium dependent, beta isoform
  • Synonyms
    PP2CB
  • Feature Type
    protein coding gene
  • IDs
    MGI:101841
    NCBI Gene: 19043
  • Gene Overview
    MyGene.info: PPM1B
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:84956741-85023991 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 55.13 cM, cytoband E4-E5
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    37 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101841
protein coding gene Chr17:84956741-85023992 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024084
protein coding gene Chr17:88157436-88222835 (+)
A/J MGP_AJ_G0024043
protein coding gene Chr17:85349330-85420117 (+)
AKR/J MGP_AKRJ_G0024012
protein coding gene Chr17:86750544-86811053 (+)
BALB/cJ MGP_BALBcJ_G0024044
protein coding gene Chr17:85199383-85269525 (+)
C3H/HeJ MGP_C3HHeJ_G0023809
protein coding gene Chr17:87653028-87664052 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024489
protein coding gene Chr17:91318681-91342737 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021928
protein coding gene Chr17:80550474-80621350 (+)
CAST/EiJ MGP_CASTEiJ_G0023288
protein coding gene Chr17:88400980-88472565 (+)
CBA/J MGP_CBAJ_G0023783
protein coding gene Chr17:95060252-95127197 (+)
DBA/2J MGP_DBA2J_G0023911
protein coding gene Chr17:83828166-83887875 (+)
FVB/NJ MGP_FVBNJ_G0023877
protein coding gene Chr17:83313280-83388120 (+)
LP/J MGP_LPJ_G0023995
protein coding gene Chr17:88931865-89006707 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023905
protein coding gene Chr17:95091710-95171495 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024534
protein coding gene Chr17:87236309-87311271 (+)
PWK/PhJ MGP_PWKPhJ_G0023033
protein coding gene Chr17:83410135-83479291 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022844
protein coding gene Chr17:84063903-84132933 (+)
WSB/EiJ MGP_WSBEiJ_G0023354
protein coding gene Chr17:88103561-88175566 (+)



Homology
more
  • Human Ortholog
    PPM1B, protein phosphatase, Mg2+/Mn2+ dependent 1B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPM1B, protein phosphatase, Mg2+/Mn2+ dependent 1B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PP2CB, PP2C-beta, PP2CBETA, PP2C-beta-X, PPC2BETAX
  • Links
    NCBI Gene ID: 5495
    neXtProt AC: NX_O75688
    UniProt: O75688

  • Chr Location
    2p21; chr2:44168803-44247330 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2027
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PPM1B
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous KO results in early pre-implantation lethality. A hypomorphic mutation results in increased sensitivity to Tnf-induced necroptosis and early death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061130 Ensembl Gene Model | MGI Sequence Detail 67251 C57BL/6J ±  kb
transcript ENSMUST00000080217 Ensembl | MGI Sequence Detail 2753 Not Applicable  
polypeptide ENSMUSP00000079107 Ensembl | MGI Sequence Detail 477 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • EC
  • InterPro Domains
    IPR036580 Phosphatase 2C, C-terminal domain superfamily
    IPR000222 PPM-type phosphatase, divalent cation binding
    IPR001932 PPM-type phosphatase domain
    IPR036457 PPM-type phosphatase domain superfamily
    IPR015655 Protein phosphatase 2C family
    IPR012911 Protein serine/threonine phosphatase 2C, C-terminal
Molecular
Reagents
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  • All nucleic 29
    Genomic 2
    cDNA 27

    Microarray probesets 10
Other
Accession IDs
less
MGD-MRK-18662
References
more
  • Summaries
    All 42
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:19661 Terasawa T, et al., Molecular cloning of a novel isotype of Mg(2+)-dependent protein phosphatase beta (type 2C beta) enriched in brain and heart. Arch Biochem Biophys. 1993 Dec;307(2):342-9
  • Latest
    J:243815 Chen W, et al., Ppm1b negatively regulates necroptosis through dephosphorylating Rip3. Nat Cell Biol. 2015 Apr;17(4):434-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory