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Ppm1b
Gene Detail
Symbol

Name
ID
Ppm1b
protein phosphatase 1B, magnesium dependent, beta isoform
MGI:101841
Synonyms
PP2CB
Feature Type
protein coding gene
Genetic Map
Chromosome 17
55.13 cM, cytoband E4-E5
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:84956741-85023991 bp, + strand
From Ensembl annotation of GRCm38

  67251 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2027  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ppm1b

Human
homologs
Human Homolog PPM1B, protein phosphatase, Mg2+/Mn2+ dependent, 1B
NCBI Gene ID 5495
neXtProt AC  NX_O75688
Human Synonyms  PP2CB, PP2C-beta, PP2CBETA, PP2C-beta-X, PPC2BETAX
Human Chr (Location)  2p21; chr2:44168861-44234603 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(24) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in early pre-implantation lethality.
 
Interactions
Ppm1b interacts with 319 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process negative regulation of defense response to virus, negative regulation of I-kappaB kinase/NF-kappaB signaling, ...
Component cytoplasm, cytosol, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (25)    Tissues (15)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 11
Western blot 14
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) Genomic(2) cDNA(26)
Microarray probesets(10)
Other database
links
Ensembl Gene ModelENSMUSG00000061130 (Evidence)
Entrez Gene19043 (Evidence)
DFCITC1589549, TC1643120, TC1587875, TC1588991, TC1580258, TC1574469, TC1611868
DoTSDT.97358946, DT.536398, DT.94284882, DT.94284889, DT.110556777, DT.101385909, DT.101737576
NIA Mouse Gene IndexU018292, U105773
EC3.1.3.16
Consensus CDS ProjectCCDS37710.1, CCDS50199.1, CCDS50200.1, CCDS50201.1
International Mouse Knockout Project StatusPpm1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061130 Ensembl Gene Model | MGI Sequence Detail 67251 C57BL/6J ±  kb
transcript ENSMUST00000080217 Ensembl | MGI Sequence Detail 2753 Not Applicable 
polypeptide ENSMUSP00000079107 Ensembl | MGI Sequence Detail 477 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(14) UniProt(9)
Polymorphisms
RFLP(2) : SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015655 Protein phosphatase 2C
InterPro IPR000222 Protein phosphatase 2C, manganese/magnesium aspartate binding site
InterPro IPR001932 Protein phosphatase 2C (PP2C)-like
InterPro IPR012911 Protein serine/threonine phosphatase 2C, C-terminal
Protein Ontology PR:000013091 protein phosphatase 1B
References
(Earliest) J:19661 Terasawa T, et al., Molecular cloning of a novel isotype of Mg(2+)-dependent protein phosphatase beta (type 2C beta) enriched in brain and heart. Arch Biochem Biophys. 1993 Dec;307(2):342-9
(Latest) J:195066 Tasdelen I, et al., The serine/threonine phosphatase PPM1B (PP2Cbeta) selectively modulates PPARgamma activity. Biochem J. 2013 Apr 1;451(1):45-53
All references(44)
Other
accession IDs
MGD-MRK-18662

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory