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Traf1 Gene Detail
Summary
  • Symbol
    Traf1
  • Name
    TNF receptor-associated factor 1
  • Synonyms
    4732496E14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:101836
    NCBI Gene: 22029
  • Gene Overview
    MyGene.info: TRAF1
Location & Maps
more
  • Sequence Map
    Chr2:34941750-34961772 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20023 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 23.13 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TRAF1, TNF receptor associated factor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRAF1, TNF receptor associated factor 1
    Orthology source: HomoloGene
  • Synonyms
    EBI6, MGC:10353
  • Links
    NCBI Gene ID: 7185
    neXtProt AC: NX_Q13077

  • Chr Location
    9q33-q34; chr9:120902393-120929173 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit abnormal T cell functionality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012272 VEGA Gene Model | MGI Sequence Detail 20023 C57BL/6J ±  kb
transcript OTTMUST00000138525 VEGA | MGI Sequence Detail 3436 Not Applicable  
polypeptide OTTMUSP00000072818 VEGA | MGI Sequence Detail 409 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    153 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000002287 TNF receptor-associated factor 1
  • InterPro Domains
    IPR002083 MATH/TRAF domain
    IPR027136 TNF receptor-associated factor 1
    IPR032070 TNF receptor-associated factor, BIRC3 binding domain
    IPR012227 TNF receptor-associated factor TRAF
    IPR008974 TRAF-like
Molecular
Reagents
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  • All nucleic 25
    cDNA 22
    Primer pair 1
    Other 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-18657, MGI:2443877
References
more
  • Summaries
    All 58
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 21
  • Earliest
    J:19898 Rothe M, et al., A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell. 1994 Aug 26;78(4):681-92
  • Latest
    J:221310 Lu YY, et al., TRAF1 is a critical regulator of cerebral ischaemia-reperfusion injury and neuronal death. Nat Commun. 2013;4:2852

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory