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Traf1 Gene Detail
Summary
  • Symbol
    Traf1
  • Name
    TNF receptor-associated factor 1
  • Synonyms
    4732496E14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:101836
    NCBI Gene: 22029
  • Gene Overview
    MyGene.info: TRAF1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:34941750-34961772 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20023 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 23.13 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TRAF1, TNF receptor associated factor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRAF1, TNF receptor associated factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EBI6, MGC:10353
  • Links
    NCBI Gene ID: 7185
    neXtProt AC: NX_Q13077
    UniProt: Q13077

  • Chr Location
    9q33.2; chr9:120902393-120929173 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit abnormal T cell functionality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000012272 VEGA Gene Model | MGI Sequence Detail 20023 C57BL/6J ±  kb
    transcript OTTMUST00000138525 VEGA | MGI Sequence Detail 3436 Not Applicable  
    polypeptide OTTMUSP00000072818 VEGA | MGI Sequence Detail 409 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      153 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 22
      Primer pair 1
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-18657, MGI:2443877
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 23
    • Earliest
      J:19898 Rothe M, et al., A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell. 1994 Aug 26;78(4):681-92
    • Latest
      J:258168 Abdul-Sater AA, et al., The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease. Nat Immunol. 2017 Jan;18(1):26-35

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory