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Tubg1 Gene Detail
Summary
  • Symbol
    Tubg1
  • Name
    tubulin, gamma 1
  • Synonyms
    1500010O08Rik, MGC:8041
  • Feature Type
    protein coding gene
  • IDs
    MGI:101834
    NCBI Gene: 103733
  • Gene Overview
    MyGene.info: TUBG1
Location & Maps
more
  • Sequence Map
    Chr11:101119938-101126419 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6482 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TUBG1, tubulin gamma 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TUBG1, tubulin gamma 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDCBM4, GCP-1, TUBG, TUBGCP1
  • Links
    NCBI Gene ID: 7283
    neXtProt AC: NX_P23258

  • Chr Location
    17q21; chr17:42609340-42615238 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 833
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TUBG1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human TUBG1 associations

Human Disease Mouse Models
       Cortical Dysplasia, Complex, with Other Brain Malformations 4; CDCBM4   OMIM: 615412
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    2
  • Targeted
    5
  • Genomic Mutations
    1 involving Tubg1
  • Incidental Mutations
Homozygous null mice display embryonic lethality and growth arrest at the blastocyst stage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002704 VEGA Gene Model | MGI Sequence Detail 6482 C57BL/6J ±  kb
transcript OTTMUST00000005341 VEGA | MGI Sequence Detail 1802 Not Applicable  
polypeptide OTTMUSP00000002532 VEGA | MGI Sequence Detail 451 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    46 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 6
    cDNA 5
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-18655, MGI:1923590, MGI:2144173, MGI:2144203
References
more
  • Summaries
    All 124
    Developmental Gene Expression 72
    Gene Ontology 17
    Phenotypes 10
  • Earliest
    J:12193 Gueth-Hallonet C, et al., gamma-Tubulin is present in acentriolar MTOCs during early mouse development. J Cell Sci. 1993 May;105(Pt 1):157-66
  • Latest
    J:228881 Gazea M, et al., Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain. Dev Biol. 2016 Jan 1;409(1):55-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory