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Tubg1
Gene Detail
Symbol

Name
ID
Tubg1
tubulin, gamma 1
MGI:101834
Synonyms
1500010O08Rik, MGC:8041
Feature Type
protein coding gene
Genetic Map
Chromosome 11
64.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:101119938-101126419 bp, + strand
From VEGA annotation of GRCm38

  6482 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:833  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TUBG1
Gene Tree: Tubg1

Human
homologs
TUBG1, tubulin, gamma 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7283
neXtProt AC: NX_P23258

Human Synonyms: CDCBM4, GCP-1, TUBG, TUBGCP1

Human Chr (Location): 17q21; chr17:42609340-42615238 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TUBG1

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Genomic Mutations involving Tubg1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality and growth arrest at the blastocyst stage.
 
Interactions
Tubg1 interacts with 54 markers (Mir1a-1, Mir1a-2, Mir30c-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cytoplasmic microtubule organization, microtubule-based process, ...
Component apical part of cell, cell leading edge, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (61 records)
Data Summary: Results (9)    Tissues (7)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
Western blot 3
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tubg1 ; ZFIN tubg1    NEW 
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000002704 (Evidence)
Ensembl Gene Model ENSMUSG00000035198 (Evidence)
Entrez Gene 103733 (Evidence)
DFCI TC1574643
DoTS DT.534487, DT.55185049
NIA Mouse Gene Index U013357
Consensus CDS Project CCDS25451.1
International Mouse Phenotyping Consortium Status Tubg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002704 VEGA Gene Model | MGI Sequence Detail 6482 C57BL/6J ±  kb
transcript OTTMUST00000005341 VEGA | MGI Sequence Detail 1802 Not Applicable 
polypeptide OTTMUSP00000002532 VEGA | MGI Sequence Detail 451 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(49 from dbSNP Build 137)    SNPs within 2kb including multiple locations(55)
Protein-related
information
ResourceIDDescription
InterPro IPR002454 Gamma tubulin
InterPro IPR000217 Tubulin
InterPro IPR017975 Tubulin, conserved site
InterPro IPR023123 Tubulin, C-terminal
InterPro IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
InterPro IPR008280 Tubulin/FtsZ, C-terminal
InterPro IPR003008 Tubulin/FtsZ, GTPase domain
Protein Ontology PR:000016825 tubulin gamma-1 chain
References
(Earliest) J:12193 Gueth-Hallonet C, et al., gamma-Tubulin is present in acentriolar MTOCs during early mouse development. J Cell Sci. 1993 May;105(Pt 1):157-66
(Latest) J:222441 Chang R, et al., A hypomorphic allele reveals an important role of inturned in mouse skeletal development. Dev Dyn. 2015 Jun;244(6):736-47
All references(116)
Other
accession IDs
MGD-MRK-18655, MGI:1923590, MGI:2144173, MGI:2144203

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory