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Elk1 Gene Detail
Summary
  • Symbol
    Elk1
  • Name
    ELK1, member of ETS oncogene family
  • Synonyms
    Elk-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101833
    NCBI Gene: 13712
  • Gene Overview
    MyGene.info: ELK1
Location & Maps
more
  • Sequence Map
    ChrX:20933395-20950608 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17214 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 16.45 cM, cytoband A1-A3
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ELK1, ELK1, ETS transcription factor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ELK1, ELK1, ETS transcription factor
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 2002
    neXtProt AC: NX_P19419

  • Chr Location
    Xp11.23; chrX:47635520-47650604 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    2
  • Targeted
    6
Targeted inactivation of this gene causes no apparent phenotype. Hemizygous males carrying the HygTk gene of a null allele are sterile, likely due to aberrant expression of the Tk gene in the testis; phenotypic correction is obtained with a second null allele that does not contain the Tk gene.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017185 VEGA Gene Model | MGI Sequence Detail 17214 C57BL/6J ±  kb
transcript OTTMUST00000041618 VEGA | MGI Sequence Detail 3548 Not Applicable  
polypeptide OTTMUSP00000018693 VEGA | MGI Sequence Detail 429 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    31 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    Genomic 2
    cDNA 17
    Primer pair 2
    Other 1

    Microarray probesets 9
Other
Accession IDs
less
MGD-MRK-18654
References
more
  • Summaries
    All 70
    Developmental Gene Expression 15
    Gene Ontology 9
    Phenotypes 15
  • Earliest
    J:19206 Giovane A, et al., Net, a new ets transcription factor that is activated by Ras. Genes Dev. 1994 Jul 1;8(13):1502-13
  • Latest
    J:226104 Wang F, et al., ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development. Am J Physiol Endocrinol Metab. 2015 Sep 1;309(5):E487-99

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory