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Gys1 Gene Detail
Summary
  • Symbol
    Gys1
  • Name
    glycogen synthase 1, muscle
  • Synonyms
    Gys3, MGS
  • Feature Type
    protein coding gene
  • IDs
    MGI:101805
    NCBI Gene: 14936
Location & Maps
more
  • Sequence Map
    Chr7:45434839-45456617 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21779 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.31 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GYS1, glycogen synthase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GYS1, glycogen synthase 1
    Orthology source: HomoloGene
  • Synonyms
    GSY, GYS
  • Links
    NCBI Gene ID: 2997
    neXtProt AC: NX_P13807

  • Chr Location
    19q13.3; chr19:48968125-48993353 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 113557
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: GYS1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Gys1 mouse models; 1 with human GYS1 associations

Human Disease Mouse Models
       Glycogen Storage Disease 0, Muscle; GSD0B   OMIM: 611556 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 5 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Gene trapped
    20
  • Targeted
    6
  • Incidental Mutations
Homozygous null mice display neonatal lethality due to impaired cardiac function and exhibit reduced reduced ventricular chamber size, dilated atria, vascular congestion, and liver hemorrhage. Mice homozygous for a knock-in allele show altered glycogen homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14936 NCBI Gene Model | MGI Sequence Detail 21779 C57BL/6J ±  kb
transcript NM_030678 RefSeq | MGI Sequence Detail 3681 C57BL/6  
polypeptide Q9Z1E4 UniProt | EBI | MGI Sequence Detail 738 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    177 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 103
    cDNA 103

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-18617, MGD-MRK-35845, MGI:107378
References
more
  • Summaries
    All 54
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:19730 Seldin MF, et al., Glycogen synthase: a putative locus for diet-induced hyperglycemia. J Clin Invest. 1994 Jul;94(1):269-76
  • Latest
    J:216806 Sinadinos C, et al., Neuronal glycogen synthesis contributes to physiological aging. Aging Cell. 2014 Oct;13(5):935-45

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory