Gys1
Gene Detail

Symbol Name ID

Gys1 glycogen synthase 1, muscle MGI:101805

Synonyms

Gys3, MGS

Feature Type

protein coding gene

Genetic Map

Chromosome 7

29.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:45434844-45456619 bp, + strand From VEGA annotation of GRCm38   21776 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:113557  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Gys1

Human homologs

Human Homolog		GYS1, glycogen synthase 1 (muscle)
NCBI Gene ID		2997
neXtProt AC		NX_P13807
Human Synonyms		GSY, GYS
Human Chr (Location)		19q13.3; chr19:49471382-49496610 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GYS1

Alleles and phenotypes

All alleles(24) : Targeted(4) Gene trapped(20)
 

Homozygous null mice display neonatal lethality with reduced heart ventricles, dilated atria, vascular congestion, and liver hemorrhage. mice homozygous for a knock-in allele exhibit altered glycogen homeostasis.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	glycogen biosynthetic process, glycogen metabolic process, ...
Component	cytoplasm, inclusion body
Function	catalytic activity, glucose binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (119)    Tissues (98)    Images (38)
Theiler Stages: 22, 23, 24, 28

Assay Type	Results
RNA in situ	117
Western blot	2

cDNA source data(94)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(98) cDNA(98)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000023845 (Evidence)
Ensembl Gene Model	ENSMUSG00000003865 (Evidence)
Entrez Gene	14936 (Evidence)
UniGene	275654
DFCI	TC1574734, TC1591031, TC1653676
NIA Mouse Gene Index	U008077
EC	2.4.1.11
Consensus CDS Project	CCDS21244.1
International Mouse Knockout Project Status	Gys1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023845	VEGA Gene Model | MGI Sequence Detail	21776	C57BL/6J
transcript	OTTMUST00000058241	VEGA | MGI Sequence Detail	3678	Not Applicable
polypeptide	OTTMUSP00000028190	VEGA | MGI Sequence Detail	738	Not Applicable

All sequences(47) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(106 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008631	Glycogen synthase
Protein Ontology	PR:000008365	glycogen [starch] synthase, muscle

References

(Earliest) J:19730 Seldin MF, et al., Glycogen synthase: a putative locus for diet-induced hyperglycemia. J Clin Invest. 1994 Jul;94(1):269-76
(Latest) J:176889 Akman HO, et al., Generation of a novel mouse model that recapitulates early and adult onset glycogenosis type IV. Hum Mol Genet. 2011 Nov 15;20(22):4430-9
All references(54)

Other accession IDs

MGD-MRK-18617, MGD-MRK-35845, MGI:107378