About   Help   FAQ
Gys1
Gene Detail
Symbol

Name
ID
Gys1
glycogen synthase 1, muscle
MGI:101805
Synonyms
Gys3, MGS
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:45434844-45456619 bp, + strand
From VEGA annotation of GRCm38

  21776 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:113557  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Gys1

Human
homologs
Human Homolog GYS1, glycogen synthase 1 (muscle)
NCBI Gene ID 2997
neXtProt AC  NX_P13807
Human Synonyms  GSY, GYS
Human Chr (Location)  19q13.3; chr19:48968125-48993353 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GYS1
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(20) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display neonatal lethality with reduced heart ventricles, dilated atria, vascular congestion, and liver hemorrhage. mice homozygous for a knock-in allele exhibit altered glycogen homeostasis.
 
Interactions
Gys1 interacts with 200 markers (Mir18, Mir18b, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process glycogen biosynthetic process, glycogen metabolic process, ...
Component cytoplasm, inclusion body, ...
Function catalytic activity, glucose binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (119)    Tissues (98)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 117
Western blot 2
cDNA source data(99)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(103) cDNA(103)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023845 (Evidence)
Ensembl Gene ModelENSMUSG00000003865 (Evidence)
Entrez Gene14936 (Evidence)
UniGene275654
DFCITC1574734, TC1653676, TC1591031
NIA Mouse Gene IndexU008077
EC2.4.1.11
Consensus CDS ProjectCCDS21244.1
International Mouse Knockout Project StatusGys1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023845 VEGA Gene Model | MGI Sequence Detail 21776 C57BL/6J ±  kb
transcript OTTMUST00000058241 VEGA | MGI Sequence Detail 3678 Not Applicable 
polypeptide OTTMUSP00000028190 VEGA | MGI Sequence Detail 738 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(177 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008631 Glycogen synthase
Protein Ontology PR:000008365 glycogen [starch] synthase, muscle
References
(Earliest) J:19730 Seldin MF, et al., Glycogen synthase: a putative locus for diet-induced hyperglycemia. J Clin Invest. 1994 Jul;94(1):269-76
(Latest) J:204966 Turnbull J, et al., Deficiency of a glycogen synthase-associated protein, Epm2aip1, causes decreased glycogen synthesis and hepatic insulin resistance. J Biol Chem. 2013 Nov 29;288(48):34627-37
All references(56)
Other
accession IDs
MGD-MRK-18617, MGD-MRK-35845, MGI:107378

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory