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mt-Nd1 Gene Detail
Summary
  • Symbol
    mt-Nd1
  • Name
    mitochondrially encoded NADH dehydrogenase 1
  • Synonyms
    0610040O15Rik, ND1, protein 1, URF1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101787
    NCBI Gene: 17716
  • Gene Overview
    MyGene.info: ND1
Location & Maps
more
  • Genetic Map
    Chromosome MT, Syntenic
Homology
more
  • Human Ortholog
    ND1, NADH dehydrogenase, subunit 1 (complex I)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ND1, NADH dehydrogenase, subunit 1 (complex I)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MTND1
  • Links
    NCBI Gene ID: 4535
    neXtProt AC: NX_P03886

  • Chr Location
    MT

Human Diseases
more
  • Diseases
    2 with human ND1 associations

Human Disease Mouse Models
       Leber Optic Atrophy   OMIM: 535000
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes; MELAS   OMIM: 540000
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
  • All Mutations and Alleles
    2
  • Gene trapped
    2
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064341 Ensembl Gene Model | MGI Sequence Detail 957 C57BL/6J ±  kb
transcript ENSMUST00000082392 Ensembl | MGI Sequence Detail 957 Not Applicable  
polypeptide ENSMUSP00000080991 Ensembl | MGI Sequence Detail 318 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    35 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000031316 NADH-ubiquinone oxidoreductase chain 1
  • EC
  • InterPro Domains
    IPR018086 NADH:ubiquinone oxidoreductase, subunit 1, conserved site
    IPR001694 NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H
Molecular
Reagents
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  • All nucleic 58
    cDNA 6
    Other 52

    Microarray probesets 1
Other
Accession IDs
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MGD-MRK-18595, MGI:1925550
References
more
  • Summaries
    All 29
    Gene Ontology 7
    Phenotypes 2
  • Earliest
    J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
  • Latest
    J:223336 Okoye I, et al., T cell metabolism. The protein LEM promotes CD8(+) T cell immunity through effects on mitochondrial respiration. (Expression of Concern 350 (6267): 1482). Science. 2015 May 29;348(6238):995-1001

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory