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Plk4
Gene Detail
 Symbol
Name
ID
Plk4
polo-like kinase 4
MGI:101783
Synonyms Sak, Stk18
Feature Type protein coding gene
Genetic Map
Chromosome 3
19.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:40800019-40816883 bp, + strand
From VEGA annotation of GRCm38

  16865 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7962  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: serine/threonine-protein kinase PLK4
Gene Tree: Plk4

Human
homologs
Human Homolog PLK4, polo-like kinase 4
NCBI Gene ID 10733
neXtProt AC  NX_O00444
Human Synonyms  SAK, STK18
Human Chr (Location)  4q28; chr4:127880861-127899224 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene die before birth. Development is arrested around E7.5. Mice heterozygous for an ENU-induced allele or gene trap alele exhibit male hypogonadism.
 
Interactions
Plk4 interacts with 154 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process centriole replication, de novo centriole assembly, ...
Component centriole, centrosome, ...
Function ATP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (135)    Tissues (50)    Images (20)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 43
RT-PCR 92
cDNA source data(81)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(82) cDNA(81) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000035882 (Evidence)
Ensembl Gene ModelENSMUSG00000025758 (Evidence)
Entrez Gene20873 (Evidence)
UniGene3794
DFCITC1576066, TC1616941
DoTSDT.101280288, DT.101387893, DT.532899, DT.91422741, DT.94352443, DT.94352452
EC2.7.11.21
PDB1MBY
Consensus CDS ProjectCCDS17328.1, CCDS57210.1
International Mouse Knockout Project StatusPlk4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035882 VEGA Gene Model | MGI Sequence Detail 16865 C57BL/6J ±  kb
transcript OTTMUST00000092020 VEGA | MGI Sequence Detail 3479 Not Applicable 
polypeptide OTTMUSP00000050763 VEGA | MGI Sequence Detail 925 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(11) UniProt(5)
Polymorphisms RFLP(2) : SNPs within 2kb(103 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000959 POLO box duplicated domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
Protein Ontology PR:000012873 serine/threonine-protein kinase PLK4
References (Earliest) J:19189 Fode C, et al., Sak, a murine protein-serine/threonine kinase that is related to the Drosophila polo kinase and involved in cell proliferation. Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6388-92
(Latest) J:203522 Zhao H, et al., The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Nat Cell Biol. 2013 Dec;15(12):1434-44
All references(49)
Other
accession IDs
MGD-MRK-18591, MGI:2139687

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory