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Lhx4
Gene Detail
Symbol

Name
ID
Lhx4
LIM homeobox protein 4
MGI:101776
Synonyms
A330062J17Rik, Gsh4, Gsh-4
Feature Type
protein coding gene
Genetic Map
Chromosome 1
67.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:155698031-155751684 bp, - strand
From VEGA annotation of GRCm38

  53654 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56497  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: LHX4
Gene Tree: Lhx4

Human
homologs
LHX4, LIM homeobox 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 89884
neXtProt AC: NX_Q969G2

Human Synonyms: CPHD4

Human Chr (Location): 1q25.2; chr1:180228803-180275053 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LHX4

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from CvDC )
 
Mutations in this gene result in abnormal lung development and neonatal lethality.
 
Interactions
Lhx4 interacts with 387 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process medial motor column neuron differentiation, motor neuron axon guidance, ...
Component intracellular, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (346)    Tissues (245)    Images (68)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 346
cDNA source data(12)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(14) Primer pair(1) Other(2)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000039744 (Evidence)
Ensembl Gene Model ENSMUSG00000026468 (Evidence)
Entrez Gene 16872 (Evidence)
DFCI TC1591698, TC1646418
DoTS DT.101714432, DT.87047006
NIA Mouse Gene Index U021919, U021920
PDB 3MMK
Consensus CDS Project CCDS48399.1
International Mouse Phenotyping Consortium Status Lhx4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039744 VEGA Gene Model | MGI Sequence Detail 53654 C57BL/6J ±  kb
transcript OTTMUST00000103346 VEGA | MGI Sequence Detail 5514 Not Applicable 
polypeptide OTTMUSP00000057721 VEGA | MGI Sequence Detail 390 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(6) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(402 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009794 LIM/homeobox protein Lhx4
References
(Earliest) J:1775 Singh G, et al., Identification of 10 murine homeobox genes. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10706-10
(Latest) J:207154 Balasubramanian R, et al., Expression of LIM-homeodomain transcription factors in the developing and mature mouse retina. Gene Expr Patterns. 2014 Jan;14(1):1-8
All references(61)
Other
accession IDs
MGD-MRK-10287, MGD-MRK-10292, MGD-MRK-18583, MGI:3624428

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory