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Lhx4
Gene Detail
 Symbol
Name
ID
Lhx4
LIM homeobox protein 4
MGI:101776
Synonyms A330062J17Rik, Gsh4, Gsh-4
Feature Type protein coding gene
Genetic Map
Chromosome 1
67.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:155698036-155751710 bp, - strand
From VEGA annotation of GRCm38

  53675 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56497  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lhx4

Human
homologs
Human Homolog LHX4, LIM homeobox 4
NCBI Gene ID 89884
neXtProt AC  NX_Q969G2
Human Synonyms  CPHD4
Human Chr (Location)  1q25.2; chr1:180230298-180275053 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LHX4
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Mutations in this gene result in abnormal lung development and neonatal lethality.
 
Interactions
Lhx4 interacts with 388 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process medial motor column neuron differentiation, motor neuron axon guidance, ...
Component intracellular, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (346)    Tissues (242)    Images (68)
Theiler Stages: 15, 17, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 346
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(14) Primer pair(1) Other(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000039744 (Evidence)
Ensembl Gene ModelENSMUSG00000026468 (Evidence)
Entrez Gene16872 (Evidence)
DFCITC1591698, TC1646418
DoTSDT.101714432, DT.87047006
NIA Mouse Gene IndexU021919, U021920
PDB3MMK
Consensus CDS ProjectCCDS48399.1
International Mouse Knockout Project StatusLhx4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039744 VEGA Gene Model | MGI Sequence Detail 53675 C57BL/6J ±  kb
transcript OTTMUST00000103346 VEGA | MGI Sequence Detail 5602 Not Applicable 
polypeptide OTTMUSP00000057721 VEGA | MGI Sequence Detail 390 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(6) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(402 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009794 LIM/homeobox protein Lhx4
References (Earliest) J:1775 Singh G, et al., Identification of 10 murine homeobox genes. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10706-10
(Latest) J:207154 Balasubramanian R, et al., Expression of LIM-homeodomain transcription factors in the developing and mature mouse retina. Gene Expr Patterns. 2014 Jan;14(1):1-8
All references(62)
Other
accession IDs
MGD-MRK-10287, MGD-MRK-10292, MGD-MRK-18583, MGI:3624428

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory