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Sntb2
Gene Detail
 Symbol
Name
ID
Sntb2
syntrophin, basic 2
MGI:101771
Synonyms Snt2
Feature Type protein coding gene
Genetic Map
Chromosome 8
53.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr8:106935750-107014192 bp, + strand
From NCBI annotation of GRCm38

  78443 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4911  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sntb2

Human
homologs
Human Homolog SNTB2, syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
NCBI Gene ID 6645
neXtProt AC  NX_Q13425
Human Synonyms  D16S2531E, EST25263, SNT2B2, SNT3, SNTL
Human Chr (Location)  16q22.1; chr16:69187147-69309052 (+)  GRCh38
Alleles
and
phenotypes
All alleles(105) : Gene trapped(102) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have no overt phenotype. They are fertile and motile with no signs of muscular dystrophy.
 
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Component cell junction, cytoplasm, ...
Function actin binding, calmodulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (14)    Tissues (11)    Images (2)
Theiler Stages: 21
Assay TypeResults
RNA in situ 14
cDNA source data(49)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(53) Genomic(3) cDNA(49) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000041308 (Evidence)
Entrez Gene20650 (Evidence)
UniGene30228
DFCITC1581422, TC1599776, TC1722911
DoTSDT.528235, DT.94201355
NIA Mouse Gene IndexU009782
Consensus CDS ProjectCCDS22642.1
International Mouse Knockout Project StatusSntb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20650 NCBI Gene Model | MGI Sequence Detail 78443 C57BL/6J ±  kb
transcript NM_009229 RefSeq | MGI Sequence Detail 4423 C57BL/6 
polypeptide Q61235 UniProt | EBI | MGI Sequence Detail 520 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(4)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(191 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR015482 Syntrophin
Protein Ontology PR:000015352 beta-2-syntrophin
Graphical View of Protein Domain Structure
References (Earliest) J:20636 Adams ME, et al., Two forms of mouse syntrophin, a 58 kd dystrophin-associated protein, differ in primary structure and tissue distribution. Neuron. 1993 Sep;11(3):531-40
(Latest) J:178524 Kim MJ, et al., alpha-Syntrophin is required for the hepatocyte growth factor-induced migration of cultured myoblasts. Exp Cell Res. 2011 Dec 10;317(20):2914-24
All references(52)
Other
accession IDs
MGD-MRK-14480, MGD-MRK-18578

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory