Sntb2
Gene Detail

Symbol Name ID

Sntb2 syntrophin, basic 2 MGI:101771

Synonyms

Snt2

Feature Type

protein coding gene

Genetic Map

Chromosome 8

53.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr8:106935750-107014192 bp, + strand From NCBI annotation of GRCm38   78443 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4911  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sntb2

Human homologs

Human Homolog		SNTB2, syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
NCBI Gene ID		6645
neXtProt AC		NX_Q13425
Human Synonyms		D16S2531E, EST25263, SNT2B2, SNT3, SNTL
Human Chr (Location)		16q22.1; chr16:69221050-69342955 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(105) : Targeted(3) Gene trapped(102)
 

Homozygous null mice have no overt phenotype. They are fertile and motile with no signs of muscular dystrophy.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Component	cell junction, cytoplasm, ...
Function	actin binding, calmodulin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (14)    Tissues (11)    Images (2)
Theiler Stages: 21

Assay Type	Results
RNA in situ	14

cDNA source data(49)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(53) Genomic(3) cDNA(49) Primer pair(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000041308 (Evidence)
Entrez Gene	20650 (Evidence)
UniGene	30228
DFCI	TC1581422, TC1599776, TC1722911
DoTS	DT.528235, DT.94201355
NIA Mouse Gene Index	U009782
Consensus CDS Project	CCDS22642.1
International Mouse Knockout Project Status	Sntb2

Sequences

Length	Strain/Species
genomic	20650	NCBI Gene Model | MGI Sequence Detail	78443	C57BL/6J
transcript	NM_009229	RefSeq | MGI Sequence Detail	4423	C57BL/6
polypeptide	Q61235	UniProt | EBI | MGI Sequence Detail	520	Not Applicable

All sequences(35) RefSeq(2) UniProt(4)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(178 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001478	PDZ domain
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR015482	Syntrophin
Protein Ontology	PR:000015352	beta-2-syntrophin

Graphical View of Protein Domain Structure

References

(Earliest) J:20636 Adams ME, et al., Two forms of mouse syntrophin, a 58 kd dystrophin-associated protein, differ in primary structure and tissue distribution. Neuron. 1993 Sep;11(3):531-40
(Latest) J:178524 Kim MJ, et al., alpha-Syntrophin is required for the hepatocyte growth factor-induced migration of cultured myoblasts. Exp Cell Res. 2011 Dec 10;317(20):2914-24
All references(53)

Other accession IDs

MGD-MRK-14480, MGD-MRK-18578