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Mcl1
Gene Detail
Symbol

Name
ID
Mcl1
myeloid cell leukemia sequence 1
MGI:101769
Synonyms
Mcl-1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
40.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:95658721-95663176 bp, + strand
From Ensembl annotation of GRCm38

  4456 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7413  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: MCL1
Protein SuperFamily: induced myeloid leukemia cell differentiation protein Mcl-1
Gene Tree: Mcl1

Human
homologs
MCL1, myeloid cell leukemia 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4170
neXtProt AC: NX_Q07820

Human Synonyms: bcl2-L-3, BCL2L3, EAT, Mcl-1, mcl1/EAT, MCL1-ES, MCL1L, MCL1S, TM

Human Chr (Location): 1q21; chr1:150574551-150579738 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(66) : Gene trapped(59) Targeted(6) Transgenic(1)
 
Homozygotes for a targeted null mutation form blastocysts which die around the time of implantation and fail to hatch in vitro. Conditional mutants shows increased apoptosis of B and T lymphocytes and arrested lymphocyte development.
 
Interactions
Mcl1 interacts with 373 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process apoptotic mitochondrial changes, apoptotic process, ...
Component Bcl-2 family protein complex, cytoplasm, ...
Function BH3 domain binding, BH domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (70)    Tissues (56)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 11
Western blot 13
RT-PCR 46
cDNA source data(244)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mcl1 ; ZFIN mcl1a, mcl1b    NEW 
Molecular
reagents
All nucleic(245) cDNA(244) Primer pair(1)
Microarray probesets(10)
Other database
links
Ensembl Gene Model ENSMUSG00000038612 (Evidence)
Entrez Gene 17210 (Evidence)
UniGene 1639
DFCI TC1571885, TC1737979, TC1762814
DoTS DT.97386582, DT.111056243, DT.536816, DT.94364640, DT.101403449, DT.103581321, DT.101403450, DT.101403451
NIA Mouse Gene Index U003579
PDB 4G35, 2JM6, 2NL9, 2ROC, 2ROD, 3D7V, 4BPI, 1WSX, 2NLA, 4BPJ, 3IO9
Consensus CDS Project CCDS57236.1
International Mouse Phenotyping Consortium Status Mcl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038612 Ensembl Gene Model | MGI Sequence Detail 4456 C57BL/6J ±  kb
transcript ENSMUST00000037947 Ensembl | MGI Sequence Detail 3485 Not Applicable 
polypeptide ENSMUSP00000044048 Ensembl | MGI Sequence Detail 331 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved site
InterPro IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved site
InterPro IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved site
InterPro IPR013281 Apoptosis regulator, Mcl-1
InterPro IPR002475 Bcl2-like
InterPro IPR026298 Blc2 family
Protein Ontology PR:000010240 induced myeloid leukemia cell differentiation protein Mcl-1
References
(Earliest) J:20820 Craig RW, et al., Human and mouse chromosomal mapping of the myeloid cell leukemia-1 gene: MCL1 maps to human chromosome 1q21, a region that is frequently altered in preneoplastic and neoplastic disease. Genomics. 1994 Sep 15;23(2):457-63
(Latest) J:220677 Carrington EM, et al., Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4044-9
All references(119)
Other
accession IDs
MGD-MRK-18576, MGI:2140009

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory