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Mcl1 Gene Detail
Summary
  • Symbol
    Mcl1
  • Name
    myeloid cell leukemia sequence 1
  • Synonyms
    Mcl-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101769
    NCBI Gene: 17210
  • Gene Overview
    MyGene.info: MCL1
Location & Maps
more
  • Sequence Map
    Chr3:95658788-95663176 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4389 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MCL1, myeloid cell leukemia 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MCL1, myeloid cell leukemia 1
    Orthology source: HomoloGene
  • Synonyms
    bcl2-L-3, BCL2L3, EAT, Mcl-1, mcl1/EAT, MCL1-ES, MCL1L, MCL1S, TM
  • Links
    NCBI Gene ID: 4170
    neXtProt AC: NX_Q07820

  • Chr Location
    1q21; chr1:150574551-150579738 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 6 alleles in 13 genetic backgrounds
    24 phenotypes from multigenic genotypes
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    69
  • Chemically induced (other)
    1
  • Gene trapped
    59
  • Radiation induced
    1
  • Targeted
    6
  • Transgenic
    2
  • Genomic Mutations
    2 involving Mcl1
Homozygotes for a targeted null mutation form blastocysts which die around the time of implantation and fail to hatch in vitro. Conditional mutants shows increased apoptosis of B and T lymphocytes and arrested lymphocyte development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053009 VEGA Gene Model | MGI Sequence Detail 4389 C57BL/6J ±  kb
transcript OTTMUST00000132601 VEGA | MGI Sequence Detail 3418 Not Applicable  
polypeptide OTTMUSP00000070680 VEGA | MGI Sequence Detail 331 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    13 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 245
    cDNA 244
    Primer pair 1

    Microarray probesets 10
Other
Accession IDs
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MGD-MRK-18576, MGI:2140009
References
more
  • Summaries
    All 120
    Developmental Gene Expression 11
    Gene Ontology 20
    Phenotypes 56
  • Earliest
    J:20820 Craig RW, et al., Human and mouse chromosomal mapping of the myeloid cell leukemia-1 gene: MCL1 maps to human chromosome 1q21, a region that is frequently altered in preneoplastic and neoplastic disease. Genomics. 1994 Sep 15;23(2):457-63
  • Latest
    J:222629 Delbridge AR, et al., Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress. Blood. 2015 May 21;125(21):3273-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory