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Ryk
Gene Detail
 Symbol
Name
ID
Ryk
receptor-like tyrosine kinase
MGI:101766
Synonyms ERK-3, Vik
Feature Type protein coding gene
Genetic Map
Chromosome 9
54.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:102834917-102908305 bp, + strand
From VEGA annotation of GRCm38

  73389 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68287  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ryk

Human
homologs
Human Homolog RYK, receptor-like tyrosine kinase
NCBI Gene ID 6259
neXtProt AC  NX_P34925
Human Synonyms  D3S3195, JTK5, JTK5A, RYK1
Human Chr (Location)  3q22; chr3:134157134-134250744 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have a distinctive craniofacial appearance, shortened limbs and postnatal mortality due to feeding and respiratory complications associated with a complete cleft of the secondary palate.
 
Interactions
Ryk interacts with 322 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process axon guidance, axonogenesis, ...
Component cytoplasm, integral component of membrane, ...
Function ATP binding, frizzled binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (319)    Tissues (155)    Images (35)
Theiler Stages: 11, 12, 13, 14, 16, 18, 20, 21, 22, 23, 28
Assay TypeResults
RNA in situ 188
Northern blot 39
RT-PCR 92
cDNA source data(121)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(128) cDNA(122) Primer pair(2) Other(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000041987 (Evidence)
Ensembl Gene ModelENSMUSG00000032547 (Evidence)
Entrez Gene20187 (Evidence)
UniGene335391
DFCITC1577564, TC1587958, TC1673000
DoTSDT.101379262, DT.535816, DT.94405930, DT.97411401
NIA Mouse Gene IndexU010938
EC2.7.10.1
Consensus CDS ProjectCCDS40747.1, CCDS57696.1
International Mouse Knockout Project StatusRyk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000041987 VEGA Gene Model | MGI Sequence Detail 73389 C57BL/6J ±  kb
transcript OTTMUST00000109960 VEGA | MGI Sequence Detail 2490 Not Applicable 
polypeptide OTTMUSP00000061267 VEGA | MGI Sequence Detail 594 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(6) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(377 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR003306 WIF domain
Protein Ontology PR:000014376 tyrosine-protein kinase RYK
References (Earliest) J:19807 Hovens CM, et al., RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11818-22
(Latest) J:190423 Macheda ML, et al., The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling. J Biol Chem. 2012 Aug 24;287(35):29312-23
All references(62)
Other
accession IDs
MGD-MRK-18573, MGI:2143310

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory