Ryk
Gene Detail

Symbol Name ID

Ryk receptor-like tyrosine kinase MGI:101766

Synonyms

ERK-3, Vik

Feature Type

protein coding gene

Genetic Map

Chromosome 9

54.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr9:102834917-102908305 bp, + strand From VEGA annotation of GRCm38   73389 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68287  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ryk

Human homologs

Human Homolog		RYK, receptor-like tyrosine kinase
NCBI Gene ID		6259
neXtProt AC		NX_P34925
Human Synonyms		D3S3195, JTK5, JTK5A, RYK1
Human Chr (Location)		3q22; chr3:133875978-133969586 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(4) Gene trapped(4)
 

Homozygous null mice have a distinctive craniofacial appearance, shortened limbs and postnatal mortality due to feeding and respiratory complications associated with a complete cleft of the secondary palate.

 

Gene Ontology (GO) classifications

All GO classifications: (38 annotations)

Process	axon guidance, axonogenesis, ...
Component	cytoplasm, integral to membrane, ...
Function	ATP binding, frizzled binding, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (319)    Tissues (155)    Images (35)
Theiler Stages: 11, 12, 13, 14, 16, 18, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	188
Northern blot	39
RT-PCR	92

cDNA source data(120)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(127) cDNA(121) Primer pair(2) Other(4)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000041987 (Evidence)
Ensembl Gene Model	ENSMUSG00000032547 (Evidence)
Entrez Gene	20187 (Evidence)
UniGene	335391
DFCI	TC1577564, TC1587958, TC1673000
DoTS	DT.101379262, DT.535816, DT.94405930, DT.97411401
NIA Mouse Gene Index	U010938
EC	2.7.10.1
Consensus CDS Project	CCDS40747.1, CCDS57696.1
International Mouse Knockout Project Status	Ryk

Sequences

Length	Strain/Species
genomic	OTTMUSG00000041987	VEGA Gene Model | MGI Sequence Detail	73389	C57BL/6J
transcript	OTTMUST00000109960	VEGA | MGI Sequence Detail	2490	Not Applicable
polypeptide	OTTMUSP00000061267	VEGA | MGI Sequence Detail	594	Not Applicable

All sequences(55) RefSeq(4) UniProt(4)

Polymorphisms

RFLP(2) : SNPs(167 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR003306	WIF domain
Protein Ontology	PR:000014376	tyrosine-protein kinase RYK

References

(Earliest) J:19807 Hovens CM, et al., RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11818-22
(Latest) J:190423 Macheda ML, et al., The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling. J Biol Chem. 2012 Aug 24;287(35):29312-23
All references(62)

Other accession IDs

MGD-MRK-18573, MGI:2143310