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Ryk Gene Detail
Summary
  • Symbol
    Ryk
  • Name
    receptor-like tyrosine kinase
  • Synonyms
    ERK-3, Vik
  • Feature Type
    protein coding gene
  • IDs
    MGI:101766
    NCBI Gene: 20187
Location & Maps
more
  • Sequence Map
    Chr9:102834917-102908305 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      73389 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 54.72 cM
  • Mapping Data
    5 experiments
Homology
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  • Human Ortholog
    RYK, receptor-like tyrosine kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RYK, receptor-like tyrosine kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    D3S3195, JTK5, JTK5A, RYK1
  • Links
    NCBI Gene ID: 6259
    neXtProt AC: NX_P34925

  • Chr Location
    3q22; chr3:134157133-134250843 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 68287
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: RYK
  • Gene Tree
    Ryk
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have a distinctive craniofacial appearance, shortened limbs and postnatal mortality due to feeding and respiratory complications associated with a complete cleft of the secondary palate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000041987 VEGA Gene Model | MGI Sequence Detail 73389 C57BL/6J ±  kb
transcript OTTMUST00000109960 VEGA | MGI Sequence Detail 2505 Not Applicable  
polypeptide OTTMUSP00000061267 VEGA | MGI Sequence Detail 594 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    370 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 128
    cDNA 122
    Primer pair 2
    Other 4

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-18573, MGI:2143310
References
more
  • Summaries
    All 60
    Developmental Gene Expression 17
    Gene Ontology 15
    Phenotypes 13
  • Earliest
    J:19807 Hovens CM, et al., RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11818-22
  • Latest
    J:226687 Morello F, et al., Frizzled3 Controls Axonal Polarity and Intermediate Target Entry during Striatal Pathway Development. J Neurosci. 2015 Oct 21;35(42):14205-19

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory