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Cdk5
Gene Detail
 Symbol
Name
ID
Cdk5
cyclin-dependent kinase 5
MGI:101765
Synonyms Crk6
Feature Type protein coding gene
Genetic Map
Chromosome 5
11.73 cM, cytoband A3-B1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:24418250-24423530 bp, - strand
From Ensembl annotation of GRCm38

  5281 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3623  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk5

Human
homologs
Human Homolog CDK5, cyclin-dependent kinase 5
NCBI Gene ID 1020
neXtProt AC  NX_Q00535
Human Synonyms  PSSALRE
Human Chr (Location)  7q36; chr7:151053812-151057965 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Incidental mutations (data from APF )
 
Homozygous mutation of this gene results in perinatal lethality and abnormalities of the cerebellum and nervous system. Mutant mice are cyanotic, hypoactive, exhibit shallow breathing, and fail to suckle.
 
Interactions
Cdk5 interacts with 133 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (145 annotations)
Process apoptotic process, associative learning, ...
Component axon, cell, ...
Function acetylcholine receptor activator activity, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (246)    Tissues (198)    Images (39)
Theiler Stages: 15, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 129
Western blot 51
RT-PCR 54
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(6) cDNA(10) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000028969 (Evidence)
Entrez Gene12568 (Evidence)
DFCITC1575084, TC1660046
DoTSDT.110653264, DT.87047333, DT.99862847
NIA Mouse Gene IndexU025993, U025994
EC2.7.11.22
Consensus CDS ProjectCCDS51434.1
International Mouse Knockout Project StatusCdk5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028969 Ensembl Gene Model | MGI Sequence Detail 5281 C57BL/6J ±  kb
transcript ENSMUST00000030814 Ensembl | MGI Sequence Detail 2050 Not Applicable 
polypeptide ENSMUSP00000030814 Ensembl | MGI Sequence Detail 292 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(5) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005258 cell division protein kinase 5
References (Earliest) J:36350 Eiden LE, et al., A nomenclature proposal for the chromogranin/secretogranin proteins. Neuroscience. 1987 Jun;21(3):1019-21
(Latest) J:211062 Zhong P, et al., Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors. J Neurosci. 2014 Apr 30;34(18):6352-66
All references(157)
Other
accession IDs
MGD-MRK-18571, MGD-MRK-2150, MGI:2141132, MGI:88507

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory