Cdk5
Gene Detail

Symbol Name ID

Cdk5 cyclin-dependent kinase 5 MGI:101765

Synonyms

Crk6

Feature Type

protein coding gene

Genetic Map

Chromosome 5

11.73 cM, cytoband A3-B1
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr5:24418250-24423530 bp, - strand From Ensembl annotation of GRCm38   5281 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3623  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk5

Human homologs

Human Homolog		CDK5, cyclin-dependent kinase 5
NCBI Gene ID		1020
neXtProt AC		NX_Q00535
Human Synonyms		PSSALRE
Human Chr (Location)		7q36; chr7:150750899-150755052 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(8) Gene trapped(1)
 

Homozygous mutation of this gene results in perinatal lethality and abnormalities of the cerebellum and nervous system. Mutant mice are cyanotic, hypoactive, exhibit shallow breathing, and fail to suckle.

 

Gene Ontology (GO) classifications

All GO classifications: (135 annotations)

Process	apoptotic process, associative learning, ...
Component	axon, cell junction, ...
Function	acetylcholine receptor activator activity, ATP binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (38 records)
Data Summary: Results (238)    Tissues (192)    Images (38)
Theiler Stages: 15, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	12
RNA in situ	129
Western blot	43
RT-PCR	54

cDNA source data(45)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(55) Genomic(6) cDNA(45) Primer pair(3) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000028969 (Evidence)
Entrez Gene	12568 (Evidence)
UniGene	298798
DFCI	TC1575084
DoTS	DT.110653264, DT.99862847
NIA Mouse Gene Index	U025994
EC	2.7.11.22
Consensus CDS Project	CCDS51434.1
International Mouse Knockout Project Status	Cdk5

Sequences

Length	Strain/Species
genomic	ENSMUSG00000028969	Ensembl Gene Model | MGI Sequence Detail	5281	C57BL/6J
transcript	ENSMUST00000030814	Ensembl | MGI Sequence Detail	2050	Not Applicable
polypeptide	ENSMUSP00000030814	Ensembl | MGI Sequence Detail	292	Not Applicable

All sequences(24) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(20 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000005258	cell division protein kinase 5

References

(Earliest) J:36350 Eiden LE, et al., A nomenclature proposal for the chromogranin/secretogranin proteins. Neuroscience. 1987 Jun;21(3):1019-21
(Latest) J:193542 Lai KO, et al., TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat Neurosci. 2012 Nov;15(11):1506-15
All references(144)

Other accession IDs

MGD-MRK-18571, MGD-MRK-2150, MGI:2141132, MGI:88507