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Cdk5
Gene Detail
Symbol

Name
ID
Cdk5
cyclin-dependent kinase 5
MGI:101765
Synonyms
Crk6
Feature Type
protein coding gene
Genetic Map
Chromosome 5
11.73 cM, cytoband A3-B1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:24418250-24423530 bp, - strand
From Ensembl annotation of GRCm38

  5281 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3623  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDK5
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk5

Human
homologs
CDK5, cyclin-dependent kinase 5
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1020
neXtProt AC: NX_Q00535

Human Synonyms: LIS7, PSSALRE

Human Chr (Location): 7q36; chr7:151053812-151057965 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CDK5

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Incidental mutations (data from APF )
 
Homozygous mutation of this gene results in perinatal lethality and abnormalities of the cerebellum and nervous system. Mutant mice are cyanotic, hypoactive, exhibit shallow breathing, and fail to suckle.
 
Interactions
Cdk5 interacts with 133 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (145 annotations)
Process apoptotic process, associative learning, ...
Component axon, cell, ...
Function acetylcholine receptor activator activity, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (43 records)
Data Summary: Results (246)    Tissues (198)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 129
Western blot 51
RT-PCR 54
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase cdk5 ; ZFIN cdk5    NEW 
Molecular
reagents
All nucleic(20) Genomic(6) cDNA(10) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000028969 (Evidence)
Entrez Gene 12568 (Evidence)
DFCI TC1575084, TC1660046
DoTS DT.110653264, DT.87047333, DT.99862847
NIA Mouse Gene Index U025993, U025994
EC 2.7.11.1
Consensus CDS Project CCDS51434.1
International Mouse Phenotyping Consortium Status Cdk5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028969 Ensembl Gene Model | MGI Sequence Detail 5281 C57BL/6J ±  kb
transcript ENSMUST00000030814 Ensembl | MGI Sequence Detail 2050 Not Applicable 
polypeptide ENSMUSP00000030814 Ensembl | MGI Sequence Detail 292 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(9) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005258 cell division protein kinase 5
References
(Earliest) J:36350 Eiden LE, et al., A nomenclature proposal for the chromogranin/secretogranin proteins. Neuroscience. 1987 Jun;21(3):1019-21
(Latest) J:222945 Tsai SY, et al., Sigma-1 receptor regulates Tau phosphorylation and axon extension by shaping p35 turnover via myristic acid. Proc Natl Acad Sci U S A. 2015 May 26;112(21):6742-7
All references(170)
Other
accession IDs
MGD-MRK-18571, MGD-MRK-2150, MGI:2141132, MGI:88507

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory