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Elk3 Gene Detail
Summary
  • Symbol
    Elk3
  • Name
    ELK3, member of ETS oncogene family
  • Synonyms
    D430049E23Rik, Erp, Net, Sap-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101762
    NCBI Gene: 13713
  • Gene Overview
    MyGene.info: ELK3
Location & Maps
more
  • Sequence Map
    Chr10:93247414-93311135 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      63722 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 48.04 cM, cytoband C-D1
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    ELK3, ELK3, ETS transcription factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ELK3, ELK3, ETS transcription factor
    Orthology source: HomoloGene
  • Synonyms
    ERP, NET, SAP2, SAP-2
  • Links
    NCBI Gene ID: 2004
    neXtProt AC: NX_P41970

  • Chr Location
    12q23; chr12:96194382-96269835 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Elk3 mouse models

Human Disease Mouse Models
       Chylothorax, Congenital   OMIM: 603523 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    1
  • Gene trapped
    12
  • Targeted
    2
  • Transposon induced
    1
  • Genomic Mutations
    2 involving Elk3
  • Incidental Mutations
Mice homozygous for a targeted mutation develop a vascular defect associated with embryonic lymphangiectasis and Egr1 upregulation in the heart and pulmonary arteries at E18.5. A large proportion of homozygotes die postnatally due to respiratory failure resulting from chylothorax.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033471 VEGA Gene Model | MGI Sequence Detail 63722 C57BL/6J ±  kb
transcript OTTMUST00000084101 VEGA | MGI Sequence Detail 4212 Not Applicable  
polypeptide OTTMUSP00000045274 VEGA | MGI Sequence Detail 409 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    627 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000007026 ETS domain-containing protein Elk-3
  • InterPro Domains
    IPR000418 Ets domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
less
  • All nucleic 95
    cDNA 93
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-18568, MGI:2442096
References
more
  • Summaries
    All 55
    Developmental Gene Expression 15
    Diseases 1
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:18267 Lopez M, et al., ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development. Mol Cell Biol. 1994 May;14(5):3292-309
  • Latest
    J:222868 Liu F, et al., Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71/ETV2. EMBO Rep. 2015 May;16(5):654-69

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory