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Elk3 Gene Detail
Summary
  • Symbol
    Elk3
  • Name
    ELK3, member of ETS oncogene family
  • Synonyms
    D430049E23Rik, Erp, Net, Sap-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101762
    NCBI Gene: 13713
  • Gene Overview
    MyGene.info: ELK3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:93247414-93311135 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      63722 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 48.04 cM, cytoband C-D1
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    ELK3, ELK3, ETS transcription factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ELK3, ELK3, ETS transcription factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ERP, NET, SAP2, SAP-2
  • Links
    NCBI Gene ID: 2004
    neXtProt AC: NX_P41970
    UniProt: P41970

  • Chr Location
    12q23.1; chr12:96194382-96269835 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Elk3 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    3 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele develop a vascular defect associated with lymphangiectasis and die prematurely due to respiratory failure resulting from chylothorax. Homozygotes for a different null allele show a transient delay in retinal primary plexus vascularization and tortuous retinal arteries.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000033471 VEGA Gene Model | MGI Sequence Detail 63722 C57BL/6J ±  kb
    transcript OTTMUST00000084101 VEGA | MGI Sequence Detail 4212 Not Applicable  
    polypeptide OTTMUSP00000045274 VEGA | MGI Sequence Detail 409 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      627 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 96
      cDNA 93
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-18568, MGI:2442096
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:243715 Ohta Y, et al., Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg. Arthritis Rheumatol. 2015 Oct;67(10):2679-90

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory