About   Help   FAQ
Elk3
Gene Detail
Symbol

Name
ID
Elk3
ELK3, member of ETS oncogene family
MGI:101762
Synonyms
D430049E23Rik, Erp, Net, Sap-2
Feature Type
protein coding gene
Genetic Map
Chromosome 10
48.04 cM, cytoband C-D1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:93247414-93311135 bp, - strand
From VEGA annotation of GRCm38

  63722 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3833  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: elk-1 transforming protein
Gene Tree: Elk3

Human
homologs
Human Homolog ELK3, ELK3, ETS-domain protein (SRF accessory protein 2)
NCBI Gene ID 2004
neXtProt AC  NX_P41970
Human Synonyms  ERP, NET, SAP2
Human Chr (Location)  12q23; chr12:96194402-96269835 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(12) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation develop a vascular defect associated with embryonic lymphangiectasis and Egr1 upregulation in the heart and pulmonary arteries at E18.5. A large proportion of homozygotes die postnatally due to respiratory failure resulting from chylothorax.
 
Human Diseases Modeled Using Mouse Elk3 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Elk3 interacts with 331 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process angiogenesis, cell differentiation, ...
Component intracellular membrane-bounded organelle, mitochondrion, ...
Function DNA binding, purine-rich negative regulatory element binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (259)    Tissues (217)    Images (72)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 244
Northern blot 14
RT-PCR 1
cDNA source data(93)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(95) cDNA(93) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000033471 (Evidence)
Ensembl Gene ModelENSMUSG00000008398 (Evidence)
Entrez Gene13713 (Evidence)
UniGene4454
DFCITC1713602, TC1577534, TC1631066
DoTSDT.103567322, DT.492676
NIA Mouse Gene IndexU032137
Consensus CDS ProjectCCDS24124.1, CCDS70097.1
International Mouse Knockout Project StatusElk3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033471 VEGA Gene Model | MGI Sequence Detail 63722 C57BL/6J ±  kb
transcript OTTMUST00000084101 VEGA | MGI Sequence Detail 4212 Not Applicable 
polypeptide OTTMUSP00000045274 VEGA | MGI Sequence Detail 409 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(6) UniProt(21)
Polymorphisms
RFLP(1) : SNPs within 2kb(641 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007026 ETS domain-containing protein Elk-3
References
(Earliest) J:18267 Lopez M, et al., ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development. Mol Cell Biol. 1994 May;14(5):3292-309
(Latest) J:201159 Zhou P, et al., Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15395-400
All references(60)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-18568, MGI:2442096

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory