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Tnip1 Gene Detail
Summary
  • Symbol
    Tnip1
  • Name
    TNFAIP3 interacting protein 1
  • Synonyms
    A20-binding inhibitor of NF-kappa B activation, ABIN1, Nef, VAN
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926194
    NCBI Gene: 57783
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:54801611-54853743 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 32.13 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    450 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926194
 protein coding gene Chr11:54801611-54853766 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018322
 protein coding gene Chr11:54402139-54457502 (-)
A/J MGP_AJ_G0018291
 protein coding gene Chr11:52376178-52430950 (-)
AKR/J MGP_AKRJ_G0018260
 protein coding gene Chr11:54092160-54148216 (-)
BALB/cJ MGP_BALBcJ_G0018262
 protein coding gene Chr11:52719864-52772234 (-)
C3H/HeJ MGP_C3HHeJ_G0018073
 protein coding gene Chr11:54030017-54087404 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018714
 protein coding gene Chr11:56064349-56117312 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016364
 protein coding gene Chr11:49811848-49864050 (-)
CAST/EiJ MGP_CASTEiJ_G0017638
 protein coding gene Chr11:54072006-54126148 (-)
CBA/J MGP_CBAJ_G0018048
 protein coding gene Chr11:58722421-58786376 (-)
DBA/2J MGP_DBA2J_G0018157
 protein coding gene Chr11:52081566-52133525 (-)
FVB/NJ MGP_FVBNJ_G0018149
 protein coding gene Chr11:51736072-51792945 (-)
LP/J MGP_LPJ_G0018232
 protein coding gene Chr11:54855677-54911271 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018175
 protein coding gene Chr11:59934276-59987913 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018756
 protein coding gene Chr11:54103301-54156491 (-)
PWK/PhJ MGP_PWKPhJ_G0017411
 protein coding gene Chr11:52625152-52683899 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017206
 protein coding gene Chr11:53896327-53949891 (-)
WSB/EiJ MGP_WSBEiJ_G0017686
 protein coding gene Chr11:53749789-53802172 (-)



Homology
more
  • Human Ortholog
    TNIP1, TNFAIP3 interacting protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNIP1, TNFAIP3 interacting protein 1
  • Synonyms
    ABIN-1, NAF1, nip40-1, VAN
  • Links
    NCBI Gene ID: 10318
    neXtProt AC: NX_Q15025
    UniProt: Q15025

  • Chr Location
    5q33.1; chr5:151029943-151093577 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    96 phenotypes from 7 alleles in 6 genetic backgrounds
    16 phenotypes from multigenic genotypes
    3 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit perinatal lethality associated with anemia and focal apoptosis in the fetal liver. Mice homozygous for a gene trap allele exhibit partial prenatal lethality and SLE-like inflammatory disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    803
  • Tissues
    38
  • cDNA Data
    74
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020400 Ensembl Gene Model | MGI Sequence Detail 52133 C57BL/6J ±  kb
    transcript ENSMUST00000018482 Ensembl | MGI Sequence Detail 2810 Not Applicable  
    polypeptide ENSMUSP00000018482 Ensembl | MGI Sequence Detail 647 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      cDNA 74

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144384
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 10
      Phenotypes 29
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory