Abca12 MGI Mouse Gene Detail - MGI:2676312 - ATP-binding cassette, sub-family A (ABC1), member 12

Abca12 Gene Detail

Symbol
Name
ID

Abca12
ATP-binding cassette, sub-family A (ABC1), member 12
MGI:2676312

Synonyms

4832428G11Rik, 4833417A11Rik

Genetic Map

Chromosome 1
Syntenic

Mapping data( 4)

Sequence Map

Chr1:71289874-71461484 bp, - strand

(From Ensembl annotation of NCBI Build 37)

Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian
homology

human; chimpanzee; dog, domestic; rat (Mammalian Orthology)

TreeFam: TF105191

Sequences

All sequences(25)

Alleles
and
phenotypes

All alleles(2) : Targeted, knock-out(2)

Mice homozygous for a null allele exhibit neonatal lethality associated with defective skin development and abnormal lung morphology.

Associated Human Diseases (1) Alleles Annotated to Human Diseases (2)

Polymorphisms

SNPs within 2kb(847 from dbSNP Build 128)

Gene Ontology
(GO)
classifications

All GO classifications(4)
Process	biological_process
Component	mitochondrial inner membrane
Function	ATP binding, nucleotide binding...
External Resources: MouseFunc

Expression

cDNA source data(6)
External Resources: Allen Brain Atlas GEO

Molecular
reagents

All nucleic(8) cDNA(8)
Microarray probesets(1)

Other database
links

Ensembl Gene Model	ENSMUSG00000050296
DoTS	DT.101285918, DT.101352006, DT.87054483, DT.97331916
UniGene	478138
DFCI	TC1590118, TC1615815, TC1616459, TC1651535
NIA Mouse Gene Index	U157376
Entrez Gene	74591
International Mouse Knockout Project Status	Abca12

Protein
domains

InterPro ID	Description
IPR003439	ABC transporter-like
IPR003593	ATPase, AAA+ type, core
IPR017871	ABC transporter, conserved site

References

(Earliest) J:65060 Kawai J et al., "Functional annotation of a full-length mouse cDNA collection." Nature 2001 Feb 8;409(6821):685-90
(Latest) J:144062 Zuo Y et al., "ABCA12 Maintains the Epidermal Lipid Permeability Barrier by Facilitating Formation of Ceramide Linoleic Esters." J Biol Chem 2008 Dec 26;283(52):36624-35

All references(7)

Other
accession IDs

MGI:1921841, MGI:3036275

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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