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Gli1 Gene Detail
 Symbol
Name
ID
Gli1
GLI-Kruppel family member GLI1
MGI:95727


Nomenclature History
Synonyms Zfp-5, Zfp5
Genetic Map
Chromosome 10
69.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 24)

Sequence Map
Chr10:126766938-126778635 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Gli1 ± 2 cM)
Protein SuperFamily: gli transforming protein
TreeFam: TF350216
Sequences
Representative Sequences Length Strain/Species Flank
genomic 14632 NCBI Gene Model | MGI Sequence Detail 11698 C57BL/6J ± Kb
transcript NM_010296 RefSeq | MGI Sequence Detail 3662 C57BL/6
polypeptide P47806 UniProt | EBI | MGI Sequence Detail 1111 Not Applicable
For the selected sequences
All sequences(18)
Alleles
and
phenotypes
All alleles(9) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(6)
Homozygotes for a targeted null mutation are apparently normal, but homozygotes that are also heterozygous for a Gli2 knockout die soon after birth with multiple defects, while Gli2 knockout heterozygotes are normally viable.
Polymorphisms RFLP(3) SNPs within 2kb(72 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cell differentiation, cerebellar cortex morphogenesis...
Component cilium, cytoplasm...
Function chromatin binding, DNA binding...
External Resources: FuncBase
Expression Literature Summary: (258 records)
Data Summary: Assays (46)    Results (233)    Tissues (119)    Images (89)
Theiler Stages: 13,15,16,17,18,19,20,21,22,23,25,28
  Assay Type Assays   Results
      RT-PCR 7   28
      RNA in situ 33   184
      Northern blot 6   21
cDNA source data(32)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(52) Genomic(2) cDNA(34) Primer pair(7) Other(9) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000025407
Consensus CDS Project CCDS24238.1
UniGene 391450
DFCI TC1584084
NIA Mouse Gene Index U032336
Entrez Gene 14632
International Mouse Knockout Project Status Gli1
Protein
domains
InterPro ID Description
IPR007087 Zinc finger, C2H2-type
IPR013087 Zinc finger, C2H2-type/integrase, DNA-binding
IPR015880 Zinc finger, C2H2-like
Graphical View of Protein Domain Structure
References
(Earliest) J:5123 Johnson DR, "Brachyphalangy, an allele of extra-toes in the mouse." Genet Res 1969 Jun;13(3):275-80
(Latest) J:155992 Ching S et al., "Targeted disruption of Sonic Hedgehog in the mouse adrenal leads to adrenocortical hypoplasia." Genesis 2009 Sep;47(9):628-37
All references(328)
Other
accession IDs
MGD-MRK-10105, MGD-MRK-15893, MGD-MRK-15948, MGI:2143787, MGI:99196

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory