Symbol
Name
ID
|
|
|
Synonyms
|
En-2
|
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Genetic Map
|
|
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Sequence Map
|
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Mammalian
homology
|
|
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Sequences
|
All sequences(18)
|
Alleles
and
phenotypes
|
All alleles(167) :
Targeted, knock-out(5)
Targeted, other(3)
Gene trapped(159)
| This locus affects anterior-posterior cerebellar patterning. Homozygous null mutants show altered foliation pattern and perform poorly in motor learning (rotarod) tests. Heterozygotes test intermediate on rotarod. Hypomorphs show no phenotypic effects. |
Associated Human Diseases (2)
Alleles Annotated to Human Diseases (1)
|
|
Polymorphisms
|
All PCR and RFLP(15) :
PCR(1)
RFLP(14)
SNPs within 2kb(16 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (107 records)
Data Summary:
Assays (37)
Results (345)
Tissues (128)
Images (73)
Theiler Stages: 11,12,13,14,15,16,17,19,20,21,22,23,24,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
Northern blot |
3 |
|
29 |
| |
RT-PCR |
4 |
|
139 |
| |
RNase protection |
1 |
|
3 |
| |
RNA in situ |
22 |
|
140 |
| |
Immunohistochemistry |
7 |
|
34 |
cDNA source data(14)
External Resources:
Allen Brain Atlas
GENSAT
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(36)
Genomic(6)
cDNA(16)
Primer pair(4)
Other(10)
Antibodies(1)
Microarray probesets(2)
|
Other database
links
|
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Protein
domains
|
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:9012
Joyner AL et al.,
"En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis [published erratum appears in Genes Dev 1987 Jul;1(5):521]"
Genes Dev 1987 Mar;1(1):29-38
(Latest)
J:156169
Cheng Y et al.,
"The Engrailed homeobox genes determine the different foliation patterns in the vermis and hemispheres of the mammalian cerebellum."
Development 2010 Feb;137(3):519-29
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All references(180)
|
Other
accession IDs
|
MGD-MRK-9498, MGD-MRK-9500, MGI:2141264
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Analysis Tools
MGI BioMart
