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Bmp6 Gene Detail
 Symbol
Name
ID
Bmp6
bone morphogenetic protein 6
MGI:88182


Nomenclature History
Synonyms D13Wsu115e, Vgr1
Genetic Map
Chromosome 13
20.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 15)

Sequence Map
Chr13:38437585-38591597 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Bmp6 ± 2 cM)
Protein SuperFamily: bone morphogenetic protein
TreeFam: TF316134
Sequences
Representative Sequences Length Strain/Species Flank
genomic 12161 NCBI Gene Model | MGI Sequence Detail 154013 C57BL/6J ± Kb
transcript NM_007556 RefSeq | MGI Sequence Detail 2410 C57BL/6
polypeptide P20722 UniProt | EBI | MGI Sequence Detail 510 Not Applicable
For the selected sequences
All sequences(21)
Alleles
and
phenotypes
All alleles(2) : Targeted, knock-out(1) Targeted, other(1)
One homozygous null mutant showed delayed ossification in the developing sternum while females of a second null mutant were smaller than normal in size.
Polymorphisms PCR(1) SNPs within 2kb(815 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(15)
Process BMP signaling pathway, cartilage development...
Component extracellular region, extracellular space...
Function cytokine activity, growth factor activity...
External Resources: MouseFunc
Expression Literature Summary: (61 records)
Data Summary: Assays (15)    Results (135)    Tissues (106)    Images (37)
Theiler Stages: 1,2,3,5,9,11,13,14,15,17,19,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      RT-PCR 4   15
      RNA in situ 7   101
      Immunohistochemistry 1   2
      Northern blot 3   17
cDNA source data(7)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(9) Primer pair(6) Other(4) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000039004
Entrez Gene 12161
International Mouse Knockout Project Status Bmp6
Protein
domains
InterPro ID Description
IPR001111 Transforming growth factor beta (TGFb), N-terminal
IPR001839 Transforming growth factor beta
IPR002405 Inhibin, alpha subunit
IPR015615 Transforming growth factor-beta-related
IPR017948 Transforming growth factor beta, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:9842 Lyons K et al., "Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily." Proc Natl Acad Sci U S A 1989 Jun;86(12):4554-8
(Latest) J:151027 Meynard D et al., "Lack of the bone morphogenetic protein BMP6 induces massive iron overload." Nat Genet 2009 Apr;41(4):478-81
All references(97)
Other
accession IDs
MGD-MRK-15388, MGD-MRK-15390, MGD-MRK-1604, MGD-MRK-34025, MGI:106333

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory