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Avpr1a Gene Detail
 Symbol
Name
ID
Avpr1a
arginine vasopressin receptor 1A
MGI:1859216


Nomenclature History
Synonyms Avpr1, V1aR
Genetic Map
Chromosome 10
cytoband D3
 
Mapping data( 2)
Sequence Map
Chr10:121885555-121890509 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat; sheep    (Mammalian Orthology)
Protein SuperFamily: vasopressin/oxytocin receptor
TreeFam: TF106499
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000020920 VEGA Gene Model | MGI Sequence Detail 4955 C57BL/6J ± Kb
transcript NM_016847 RefSeq | MGI Sequence Detail 2671 -
polypeptide Q62463 UniProt | EBI | MGI Sequence Detail 423 Not Applicable
For the selected sequences
All sequences(20)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(2) Targeted, other(1)
Mice homozygous for disruptions in this gene display a stimulus processing deficit similar to that seen in schizophrenia. Anxiety-like behaviors are reduced in males but not females. B cell development is also affected.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms SNPs within 2kb(68 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(12)
Process G-protein coupled receptor protein signaling pathway, regulation of systemic arterial blood pressure by vasopressin...
Component integral to membrane, membrane...
Function G-protein coupled receptor activity, receptor activity...
External Resources: MouseFunc
Expression Literature Summary: (3 records)
Data Summary: Assays (2)    Results (90)    Tissues (53)    Images (2)
Theiler Stages: 28
  Assay Type Assays   Results
      RT-PCR 1   38
      In situ reporter (knock in) 1   52
cDNA source data(11)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000020123
DoTS DT.487709
UniGene 4351
DFCI TC1583605
NIA Mouse Gene Index U086756
Entrez Gene 54140
VEGA Gene Model OTTMUSG00000020920
International Mouse Knockout Project Status Avpr1a
Protein
domains
InterPro ID Description
IPR000276 7TM GPCR, rhodopsin-like
IPR001224 Vasopressin V1A receptor
IPR001817 Vasopressin receptor
IPR015076 Domain of unknown function DUF1856
IPR017452 GPCR, rhodopsin-like superfamily
Graphical View of Protein Domain Structure
References
(Earliest) J:75961 Wesley VJ et al., "Agonist-specific, high-affinity binding epitopes are contributed by an arginine in the N-terminus of the human oxytocin receptor." Biochemistry 2002 Apr 23;41(16):5086-92
(Latest) J:148625 Li JD et al., "Vasopressin receptor V1a regulates circadian rhythms of locomotor activity and expression of clock-controlled genes in the suprachiasmatic nuclei." Am J Physiol Regul Integr Comp Physiol 2009 Mar;296(3):R824-30
All references(25)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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