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Atp1a1 Gene Detail
 Symbol
Name
ID
Atp1a1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
MGI:88105

Nomenclature History
Synonyms Atpa-1
Genetic Map
Chromosome 3
48.4 cM, cytoband F3
Detailed Genetic Map ± 1 cM
 
Mapping data( 12)

Sequence Map
Chr3:101380142-101408526 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; pig, domestic; rat; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Atp1a1 ± 2 cM)
Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
TreeFam: TF312838
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016447 VEGA Gene Model | MGI Sequence Detail 28385 C57BL/6J ± Kb
transcript NM_144900 RefSeq | MGI Sequence Detail 3686 FVB/N
polypeptide Q8VDN2 UniProt | EBI | MGI Sequence Detail 1023 Not Applicable
For the selected sequences
All sequences(123)
Alleles
and
phenotypes 		All alleles(18) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(16)
Mice homozygous for disruptions in this gene have a lethal phenotype. Heterozygotes display increased anxiety and decreased exploratory behavior in a new environment.
Polymorphisms RFLP(3) SNPs within 2kb(147 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process ATP biosynthetic process, cation transport...
Component basolateral plasma membrane, integral to membrane...
Function 4-nitrophenylphosphatase activity, ATP binding...
External Resources: FuncBase
Expression Literature Summary: (22 records)
Data Summary: Assays (10)    Results (53)    Tissues (21)    Images (4)
Theiler Stages: 3,4,5,24,25,26,28
  Assay Type Assays   Results
      Western blot 5   19
      Immunohistochemistry 1   6
      Northern blot 4   28
cDNA source data(735)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(745) Genomic(4) cDNA(741) Antibodies(3)
Microarray probesets(3)
Other database
links
EC 3.6.1.37, 3.6.3.9
Ensembl Gene Model ENSMUSG00000033161
DoTS DT.101183734, DT.101239863, DT.101368510, DT.496244, DT.94145409, DT.94146579, DT.94202066, DT.99872006
Consensus CDS Project CCDS17683.1
UniGene 280103
DFCI TC1573729, TC1706001, TC1751293
NIA Mouse Gene Index U024436
Entrez Gene 11928
VEGA Gene Model OTTMUSG00000016447
International Mouse Knockout Project Status Atp1a1
Protein
domains
InterPro ID Description
IPR001757 ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
IPR004014 ATPase, P-type cation-transporter, N-terminal
IPR005775 ATPase, P-type cation exchange, alpha subunit, eukaryotic
IPR005834 Haloacid dehalogenase-like hydrolase
IPR006068 ATPase, P-type cation-transporter, C-terminal
IPR006069 ATPase, P-type cation exchange, alpha subunit
IPR008250 ATPase, P-type, ATPase-associated domain
IPR018303 ATPase, P-type phosphorylation site
Graphical View of Protein Domain Structure
References
(Earliest) J:7397 Levenson R et al., "Molecular cloning of the mouse ouabain-resistance gene." Proc Natl Acad Sci U S A 1984 Mar;81(5):1489-93
(Latest) J:156424 Bossuyt J et al., "Isoform specificity of the Na/K-ATPase association and regulation by phospholemman." J Biol Chem 2009 Sep 25;284(39):26749-57
All references(66)
Other
accession IDs 		MGD-MRK-1457, MGD-MRK-1470, MGI:2387620
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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