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Axl Gene Detail
 Symbol
Name
ID
Axl
AXL receptor tyrosine kinase
MGI:1347244

Nomenclature History
Synonyms Ark, Tyro7, Ufo
Genetic Map
Chromosome 7
6.0 cM, cytoband A3-B1
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr7:26542292-26573724 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Axl ± 2 cM)
Protein SuperFamily: tyrosine-protein kinase receptor TYRO3/UFO/MER type
TreeFam: TF317402
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000022291 VEGA Gene Model | MGI Sequence Detail 31433 C57BL/6J ± Kb
transcript NM_009465 RefSeq | MGI Sequence Detail 4119 C57BL/6
polypeptide Q00993 UniProt | EBI | MGI Sequence Detail 888 Not Applicable
For the selected sequences
All sequences(38)
Alleles
and
phenotypes 		All alleles(2) : Targeted, knock-out(1) Targeted, other(1)
Homozygous mutant mice are phenotypically normal, however in conjunction with mutations in other related receptor tyrosine kinases, mutations of this gene results in fertility defects, autoimmunity abnormalities, and aberrant apoptosis.
Polymorphisms SNPs within 2kb(121 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cellular response to extracellular stimulus, protein amino acid phosphorylation...
Component integral to membrane, integral to plasma membrane...
Function ATP binding, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (5 records)
Data Summary: Assays (9)    Results (264)    Tissues (144)    Images (120)
Theiler Stages: 3,4,13,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      RT-PCR 6   55
      In situ reporter (knock in) 1   188
      RNA in situ 1   13
      Northern blot 1   8
cDNA source data(18)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(20) cDNA(18) Primer pair(2)
Microarray probesets(2)
Other database
links
EC 2.7.10.1
Ensembl Gene Model ENSMUSG00000002602
DoTS DT.101227378, DT.101280926, DT.101358309, DT.101737745, DT.495418, DT.91335793
Consensus CDS Project CCDS20996.1
DFCI TC1574561, TC1576432, TC1580210, TC1686075
NIA Mouse Gene Index U028284
Entrez Gene 26362
VEGA Gene Model OTTMUSG00000022291
International Mouse Knockout Project Status Axl
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR001245 Tyrosine-protein kinase, catalytic domain
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like
IPR008266 Tyrosine-protein kinase, active site
IPR008957 Fibronectin, type III-like fold
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013783 Immunoglobulin-like fold
IPR015775 Tyrosine-protein kinase, receptor Axl-related
IPR017441 Protein kinase, ATP binding site
IPR020635 Tyrosine-protein kinase, subgroup, catalytic domain
IPR020685 Tyrosine-protein kinase
Graphical View of Protein Domain Structure
References
(Earliest) J:18115 Janssen JW et al., "A novel putative tyrosine kinase receptor with oncogenic potential." Oncogene 1991 Nov;6(11):2113-20
(Latest) J:152808 Williams BJ et al., "TAM receptors are dispensable in the phagocytosis and killing of bacteria." Cell Immunol 2009;259(2):128-34
All references(34)
Other
accession IDs 		MGD-MRK-15343, MGI:2141908, MGI:98896
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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