About   Help   FAQ
Avpr1b Gene Detail
 Symbol
Name
ID
Avpr1b
arginine vasopressin receptor 1B
MGI:1347010


Nomenclature History
Synonyms AVPR3, V1BR, V1bR, V3/V1b, V3/V1b pituitary vasopressin receptor, VPR3
Genetic Map
Chromosome 1
cytoband E4
 
Mapping data( 3)
Sequence Map
Chr1:133495816-133508577 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: vasopressin/oxytocin receptor
TreeFam: TF106499
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000020888 VEGA Gene Model | MGI Sequence Detail 12762 C57BL/6J ± Kb
transcript NM_011924 RefSeq | MGI Sequence Detail 4148 C57BL/6
polypeptide Q9WU02 UniProt | EBI | MGI Sequence Detail 421 Not Applicable
For the selected sequences
All sequences(16)
Alleles
and
phenotypes
All alleles(5) : Targeted, knock-out(4) Targeted, other(1)
Homozygous null mice for one allele display disregulation of the hypothalamic-pituitary-adrenal axis activity under stress and resting conditions. Homozygous null mice for other alleles display decreased aggression or an increased propensity for seizures.
Polymorphisms SNPs within 2kb(89 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process G-protein coupled receptor protein signaling pathway, regulation of systemic arterial blood pressure by vasopressin...
Component integral to membrane, membrane...
Function G-protein coupled receptor activity, receptor activity...
External Resources: FuncBase
Expression Literature Summary: (1 records)
Data Summary: Assays (2)    Results (94)    Tissues (53)    Images (11)
Theiler Stages: 28
  Assay Type Assays   Results
      RT-PCR 1   38
      In situ reporter (knock in) 1   56
cDNA source data(2)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(4) cDNA(2) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000026432
DoTS DT.91367635
Consensus CDS Project CCDS35703.1
UniGene 89986
DFCI TC1589895
NIA Mouse Gene Index U000781
Entrez Gene 26361
VEGA Gene Model OTTMUSG00000020888
International Mouse Knockout Project Status Avpr1b
Protein
domains
InterPro ID Description
IPR000276 7TM GPCR, rhodopsin-like
IPR000628 Vasopressin VIB receptor
IPR001817 Vasopressin receptor
IPR015076 Domain of unknown function DUF1856
IPR017452 GPCR, rhodopsin-like superfamily
Graphical View of Protein Domain Structure
References
(Earliest) J:55963 Ventura MA et al., "Gene and cDNA cloning and characterization of the mouse V3/V1b pituitary vasopressin receptor." J Mol Endocrinol 1999 Jun;22(3):251-60
(Latest) J:150596 Caldwell HK et al., "Persistence of reduced aggression in vasopressin 1b receptor knockout mice on a more 'wild' background." Physiol Behav 2009 Apr 20;97(1):131-4
All references(24)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/06/2010
MGI_4.32
Web browser compatibility
The Jackson Laboratory