Symbol
Name
ID
|
Cacna1c
calcium channel, voltage-dependent, L type, alpha 1C subunit
MGI:103013
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Nomenclature History
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Synonyms
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(alpha)1 subunit, Cav1.2, Cchl1a1, L-type Cav1.2
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
|
All sequences(49)
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Alleles
and
phenotypes
|
All alleles(8) :
Targeted, knock-out(2)
Targeted, other(4)
Gene trapped(2)
| Mice homozygous for mutations that inactivate the gene do not survive to term. Selective ablation in beta cells resulted in impaired insulin secretion and systemic glucose intolerance. Heterozygotes were hypozctive, showed increased anxiety, and poor motor coordination. |
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Polymorphisms
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SNPs within 2kb(4155 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (13 records)
Data Summary:
Assays (12)
Results (205)
Tissues (113)
Images (88)
Theiler Stages: 15,17,19,20,22,23,24,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
1 |
|
2 |
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RT-PCR |
6 |
|
55 |
| |
In situ reporter (knock in) |
1 |
|
101 |
| |
Immunohistochemistry |
2 |
|
30 |
| |
Northern blot |
1 |
|
8 |
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RNase protection |
1 |
|
9 |
cDNA source data(25)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(33)
Genomic(2)
cDNA(26)
Primer pair(5)
Antibodies(4)
Microarray probesets(2)
|
Other database
links
|
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Protein
domains
|
| InterPro ID |
Description |
| IPR002077 |
Voltage-dependent calcium channel, alpha-1 subunit |
| IPR005446 |
Voltage-dependent calcium channel, L-type, alpha-1 subunit |
| IPR005451 |
Voltage-dependent calcium channel, L-type, alpha-1C subunit |
| IPR005821 |
Ion transport |
| IPR014873 |
Voltage-dependent calcium channel, alpha-1 subunit, IQ domain |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:26177
Perez-Reyes E et al.,
"Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes."
J Biol Chem 1990 Nov 25;265(33):20430-6
(Latest)
J:152610
Tang ZZ et al.,
"Developmental control of CaV1.2 L-type calcium channel splicing by Fox proteins."
Mol Cell Biol 2009 Sep;29(17):4757-65
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All references(55)
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Other
accession IDs
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MGD-MRK-23850
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