About   Help   FAQ
Naip1 Gene Detail
 Symbol
Name
ID
Naip1
NLR family, apoptosis inhibitory protein 1
MGI:1298223


Nomenclature History
Synonyms Birc1a, D13Lsd1, Naip
Genetic Map
Chromosome 13
54.0 cM, cytoband D1-D3
Detailed Genetic Map ± 1 cM
 
Mapping data( 13)

Sequence Map
Chr13:101177749-101216466 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human    (Mammalian Orthology)
Comparative Map (Mouse/Human Naip1 ± 2 cM)
Protein SuperFamily: neuronal apoptosis inhibitory protein
TreeFam: TF105356
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000021640 Ensembl Gene Model | MGI Sequence Detail 38718 C57BL/6J ± Kb
transcript NM_008670 RefSeq | MGI Sequence Detail 5361 -
polypeptide Q9QWK5 UniProt | EBI | MGI Sequence Detail 1403 Not Applicable
For the selected sequences
All sequences(22)
Alleles
and
phenotypes
All alleles(2) : Targeted, knock-out(2)
Mice homozygous for disruptions in this gene display a normal phenotype.
Polymorphisms PCR(3) SNPs within 2kb(281 from dbSNP Build 128)   SNPs within 2kb including multiple locations(331)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process apoptosis
Component intracellular
Function ATP binding, metal ion binding...
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (4)    Results (96)    Tissues (51)    Images (1)
Theiler Stages: 22,28
  Assay Type Assays   Results
      RT-PCR 3   48
      In situ reporter (knock in) 1   48
cDNA source data(8)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(33) Genomic(19) cDNA(8) Primer pair(5) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000021640
DoTS DT.485607, DT.91335568
Consensus CDS Project CCDS26729.1
UniGene 6898
NIA Mouse Gene Index U035107
Entrez Gene 17940
International Mouse Knockout Project Status Naip1
Protein
domains
InterPro ID Description
IPR001370 Proteinase inhibitor I32, inhibitor of apoptosis
IPR003593 ATPase, AAA+ type, core
IPR007111 NACHT nucleoside triphosphatase
Graphical View of Protein Domain Structure
References
(Earliest) J:37707 Scharf JM et al., "The mouse region syntenic for human spinal muscular atrophy lies within the Lgn1 critical interval and contains multiple copies of Naip exon 5." Genomics 1996 Dec 15;38(3):405-17
(Latest) J:155702 Whitfield NN et al., "Mouse macrophages are permissive to motile legionella species that fail to trigger pyroptosis." Infect Immun 2010 Jan;78(1):423-32
All references(22)
Other
accession IDs
MGD-MRK-38374, MGD-MRK-39477, MGI:109329, MGI:109478, MGI:2145401

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/06/2010
MGI_4.32
Web browser compatibility
The Jackson Laboratory