About   Help   FAQ
Mfng Gene Detail
 Symbol
Name
ID
Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MGI:1095404


Nomenclature History
Synonyms manic fringe
Genetic Map
Chromosome 15
44.8 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr15:78586312-78603905 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Mfng ± 2 cM)
Protein SuperFamily: beta-1,3-N-acetylglucosaminyltransferase, radical fringe type
TreeFam: TF324207
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000021012 VEGA Gene Model | MGI Sequence Detail 17594 C57BL/6J ± Kb
transcript NM_008595 RefSeq | MGI Sequence Detail 1834 C57BL/6
polypeptide O09008 UniProt | EBI | MGI Sequence Detail 321 Not Applicable
For the selected sequences
All sequences(18)
Alleles
and
phenotypes
All alleles(5) : Targeted, knock-out(3) Targeted, other(1) Gene trapped(1)
Mice homozygous for a null mutation are viable and fertile with normal pancreatic development, morphology and physiology.
Polymorphisms RFLP(1) SNPs within 2kb(40 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(12)
Process multicellular organismal development, pattern specification process...
Component Golgi apparatus, integral to Golgi membrane...
Function O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity, transferase activity...
External Resources: MouseFunc
Expression Literature Summary: (17 records)
Data Summary: Assays (5)    Results (30)    Tissues (26)    Images (10)
Theiler Stages: 12,14,17,20,22,25,28
  Assay Type Assays   Results
      RNA in situ 3   20
      Northern blot 2   10
cDNA source data(42)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents
All nucleic(48) Genomic(4) cDNA(42) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
EC 2.4.1.222
Ensembl Gene Model ENSMUSG00000018169
DoTS DT.532638
UniGene 149235
PDB 2J0A, 2J0B
DFCI TC1578954
NIA Mouse Gene Index U036390
Entrez Gene 17305
VEGA Gene Model OTTMUSG00000021012
International Mouse Knockout Project Status Mfng
Protein
domains
InterPro ID Description
IPR003378 Fringe-like
IPR017374 Fringe
Graphical View of Protein Domain Structure
References
(Earliest) J:41128 Johnston SH et al., "A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway." Development 1997 Jun;124(11):2245-54
(Latest) J:149312 Moran JL et al., "Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain." Dev Dyn 2009 May 28;238(7):1803-1812
All references(23)
Other
accession IDs
MGI:2146229

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/20/2009
MGI_4.31
Web browser compatibility
The Jackson Laboratory