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Cttn Gene Detail
 Symbol
Name
ID
Cttn
cortactin
MGI:99695


Nomenclature History
Synonyms 1110020L01Rik, Ems1
Genetic Map
Chromosome 7
Syntenic
 
Mapping data( 4)
Sequence Map
Chr7:151621638-151656914 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF318935
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016455 VEGA Gene Model | MGI Sequence Detail 35277 C57BL/6J ± Kb
transcript NM_007803 RefSeq | MGI Sequence Detail 3029 C57BL/6
polypeptide Q60598 UniProt | EBI | MGI Sequence Detail 546 Not Applicable
For the selected sequences
All sequences(61)
Alleles
and
phenotypes
All alleles(10) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(8)
In homozygous null MEFs cell migration and actin distribution are normal.
Polymorphisms SNPs within 2kb(157 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Component cell cortex, cell projection...
Function protein binding
External Resources: FuncBase
Expression Literature Summary: (9 records)
Data Summary: Assays (5)    Results (69)    Tissues (36)    Images (6)
Theiler Stages: 15,17,21,28
  Assay Type Assays   Results
      RNA in situ 4   65
      Immunohistochemistry 1   4
cDNA source data(22)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(23) cDNA(22) Other(1) Antibodies(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000031078
DoTS DT.101169998, DT.101409339, DT.110765023, DT.494854, DT.94375434
Consensus CDS Project CCDS22049.1
PDB 2F9X
DFCI TC1573932, TC1595599
NIA Mouse Gene Index U029524, U090132, U156273, U282633
Entrez Gene 13043
VEGA Gene Model OTTMUSG00000016455
International Mouse Knockout Project Status Cttn
Protein
domains
InterPro ID Description
IPR000108 Neutrophil cytosol factor 2
IPR001452 Src homology-3 domain
IPR003134 Hs1/Cortactin
IPR015503 Cortactin
IPR020473 Src homology-3, region
Graphical View of Protein Domain Structure
References
(Earliest) J:19932 Zhan X et al., "Murine cortactin is phosphorylated in response to fibroblast growth factor-1 on tyrosine residues late in the G1 phase of the BALB/c 3T3 cell cycle." J Biol Chem 1993 Nov 15;268(32):24427-31
(Latest) J:156197 Lai FP et al., "Cortactin promotes migration and platelet-derived growth factor-induced actin reorganization by signaling to Rho-GTPases." Mol Biol Cell 2009 Jul;20(14):3209-23
All references(36)
Other
accession IDs
MGD-MRK-16480, MGI:1915873

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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