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Ext2 Gene Detail
 Symbol
Name
ID
Ext2
exostoses (multiple) 2
MGI:108050

Nomenclature History
Genetic Map
Chromosome 2
51.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr2:93535788-93662725 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Ext2 ± 2 cM)
TreeFam: TF314231
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000014564 VEGA Gene Model | MGI Sequence Detail 126938 C57BL/6J ± Kb
transcript NM_010163 RefSeq | MGI Sequence Detail 2875 C57BL/6
polypeptide P70428 UniProt | EBI | MGI Sequence Detail 718 Not Applicable
For the selected sequences
All sequences(56)
Alleles
and
phenotypes 		All alleles(3) : Targeted, knock-out(1) Gene trapped(2)
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms PCR(1) SNPs within 2kb(702 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell differentiation, heparan sulfate proteoglycan biosynthetic process...
Component endoplasmic reticulum, Golgi apparatus...
Function glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity, heparan sulfate N-acetylglucosaminyltransferase activity...
External Resources: FuncBase
Expression Literature Summary: (5 records)
Data Summary: Assays (4)    Results (44)    Tissues (40)    Images (8)
Theiler Stages: 10,13,17,18,19,21,23,24,25,26,28
  Assay Type Assays   Results
      RT-PCR 1   7
      RNA in situ 2   25
      Northern blot 1   12
cDNA source data(111)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(116) Genomic(2) cDNA(112) Primer pair(2)
Microarray probesets(2)
Other database
links
EC 2.4.1.224, 2.4.1.225
Ensembl Gene Model ENSMUSG00000027198
DoTS DT.101297615, DT.533051, DT.91413473, DT.94340063, DT.99843674
Consensus CDS Project CCDS16456.1
UniGene 4336
DFCI TC1574051, TC1597007, TC1649194
NIA Mouse Gene Index U023051
Entrez Gene 14043
VEGA Gene Model OTTMUSG00000014564
International Mouse Knockout Project Status Ext2
Protein
domains
InterPro ID Description
IPR004263 Exostosin-like
IPR015338 EXTL2, alpha-1,4-N-acetylhexosaminyltransferase
Graphical View of Protein Domain Structure
References
(Earliest) J:48118 Hennekam RC, "Hereditary multiple exostoses." J Med Genet 1991 Apr;28(4):262-6
(Latest) J:150524 Chan JA et al., "Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses." Nat Neurosci 2009 Apr;12(4):409-17
All references(20)
Other
accession IDs 		MGD-MRK-37086, MGI:2139111
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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