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St8sia1 Gene Detail
 Symbol
Name
ID
St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
MGI:106011


Nomenclature History
Synonyms 9330109E03Rik, alpha-2,8-sialyltransferase, GD3 synthase, GD3S, Siat8, Siat8a, ST8Sia I
Genetic Map
Chromosome 6
60.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr6:142770065-142912972 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human St8sia1 ± 2 cM)
Protein SuperFamily: sialyltransferase
TreeFam: TF323961
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000022470 VEGA Gene Model | MGI Sequence Detail 142908 C57BL/6J ± Kb
transcript NM_011374 RefSeq | MGI Sequence Detail 8995 -
polypeptide Q64687 UniProt | EBI | MGI Sequence Detail 355 Not Applicable
For the selected sequences
All sequences(33)
Alleles
and
phenotypes
All alleles(9) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(7)
Polymorphisms RFLP(1) SNPs within 2kb(518 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(14)
Process cellular response to heat, lipid biosynthetic process...
Component Golgi apparatus, integral to Golgi membrane...
Function alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity, sialyltransferase activity...
External Resources: MouseFunc
Expression Literature Summary: (8 records)
Data Summary: Assays (6)    Results (97)    Tissues (54)    Images (4)
Theiler Stages: 12,20,22,23,24,26,28
  Assay Type Assays   Results
      RT-PCR 5   92
      Northern blot 1   5
cDNA source data(34)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(39) cDNA(35) Primer pair(4)
Microarray probesets(3)
Other database
links
EC 2.4.99.8
Ensembl Gene Model ENSMUSG00000030283
DoTS DT.110501192, DT.40158316, DT.91419080, DT.91423797
UniGene 260838
DFCI TC1583140, TC1587079, TC1646422
NIA Mouse Gene Index U028008
Entrez Gene 20449
VEGA Gene Model OTTMUSG00000022470
International Mouse Knockout Project Status St8sia1
Protein
domains
InterPro ID Description
IPR001675 Glycosyl transferase, family 29
IPR012163 Sialyltransferase
Graphical View of Protein Domain Structure
References
(Earliest) J:26814 Yoshida Y et al., "Molecular cloning of Sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase from mouse brain." J Biol Chem 1995 Jun 16;270(24):14628-33
(Latest) J:153974 Tajima O et al., "Dysfunction of muscarinic acetylcholine receptors as a substantial basis for progressive neurological deterioration in GM3-only mice." Behav Brain Res 2010 Jan 5;206(1):101-8
All references(30)
Other
accession IDs
MGD-MRK-18769, MGD-MRK-33693, MGI:2444866

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory