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Itgb6 Gene Detail
 Symbol
Name
ID
Itgb6
integrin beta 6
MGI:96615


Nomenclature History
Synonyms 2210409C20Rik, 4831415H04Rik
Genetic Map
Chromosome 2
34.0 cM, cytoband C3
Detailed Genetic Map ± 1 cM
 
Mapping data( 2)

Sequence Map
Chr2:60436349-60560700 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Itgb6 ± 2 cM)
Protein SuperFamily: integrin, beta subunit
TreeFam: TF105392
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000012790 VEGA Gene Model | MGI Sequence Detail 124352 C57BL/6J ± Kb
transcript NM_001159564 RefSeq | MGI Sequence Detail 4894 C57BL/6
polypeptide Q9Z0T9 UniProt | EBI | MGI Sequence Detail 787 Not Applicable
For the selected sequences
All sequences(26)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(1) Targeted, other(2)
Homozygotes for a targeted null mutation exhibit baldness associated with macrophage infiltration of skin, exaggerated pulmonary inflammation, and an impaired mucosal mast cell response to nematode infection.
Associated Human Diseases (2)   Alleles Annotated to Human Diseases (1)   Phenotype Images (3)  
Polymorphisms SNPs within 2kb(738 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(14)
Process cell adhesion, cell-matrix adhesion...
Component integral to membrane, integrin complex...
Function binding, integrin binding...
External Resources: MouseFunc
Expression Literature Summary: (5 records)
Data Summary: Assays (3)    Results (44)    Tissues (10)
Theiler Stages: 19,22,25,28
  Assay Type Assays   Results
      RT-PCR 1   6
      RNA in situ 1   37
      Northern blot 1   1
cDNA source data(13)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(15) cDNA(13) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000026971
DoTS DT.101175104, DT.101714402, DT.40173788, DT.91321808, DT.91404868, DT.91410799
UniGene 98193
DFCI TC1584641, TC1596665, TC1614238, TC1770157
NIA Mouse Gene Index U022670
Entrez Gene 16420
VEGA Gene Model OTTMUSG00000012790
International Mouse Knockout Project Status Itgb6
Protein
domains
InterPro ID Description
IPR001169 Integrin beta subunit, C-terminal
IPR002035 von Willebrand factor, type A
IPR002369 Integrin beta subunit, N-terminal
IPR003659 Plexin/semaphorin/integrin
IPR012012 Integrin beta subunit, subgroup
IPR012896 Integrin beta subunit, tail
IPR013032 EGF-like region, conserved site
IPR013111 EGF, extracellular
IPR014836 Integrin beta subunit, cytoplasmic
IPR015436 Integrin beta-6 subunit, C-terminal
IPR015812 Integrin beta subunit
Graphical View of Protein Domain Structure
References
(Earliest) J:3170 Morse HC 3rd, "Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563]" J Immunol 1992 Nov 15;149(10):3129-34
(Latest) J:145991 Aluwihare P et al., "Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice." J Cell Sci 2009 Jan 15;122(Pt 2):227-32
All references(29)
Other
accession IDs
MGD-MRK-11494, MGI:1917381, MGI:1925805

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory