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Id3 Gene Detail
 Symbol
Name
ID
Id3
inhibitor of DNA binding 3
MGI:96398

Nomenclature History
Synonyms bHLHb25, HLH462, Idb3
Genetic Map
Chromosome 4
66.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 8)

Sequence Map
Chr4:135699412-135701670 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Id3 ± 2 cM)
Protein SuperFamily: DNA-binding protein inhibitor, ID type
TreeFam: TF326217
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000009864 VEGA Gene Model | MGI Sequence Detail 2259 C57BL/6J ± Kb
transcript NM_008321 RefSeq | MGI Sequence Detail 964 C57BL/6
polypeptide P41133 UniProt | EBI | MGI Sequence Detail 119 Not Applicable
For the selected sequences
All sequences(36)
Alleles
and
phenotypes 		All alleles(4) : Targeted, knock-out(2) Gene trapped(2)
Homozygotes for a targeted null mutation exhibit compromised humoral immunity. Homozygotes for knockout alleles of both Id1 and Id3 die by embryonic day 13.5 with vascular malformations of the forebrain.
Polymorphisms RFLP(1) SNPs within 2kb(14 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process epithelial cell differentiation, heart development...
Component cytoplasm, nucleus...
Function protein binding, protein domain specific binding...
External Resources: FuncBase
Expression Literature Summary: (38 records)
Data Summary: Assays (15)    Results (126)    Tissues (98)    Images (9)
Theiler Stages: 2,3,4,5,15,16,17,18,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 1   3
      RT-PCR 6   43
      RNA in situ 5   58
      Immunohistochemistry 1   3
      Northern blot 2   19
cDNA source data(185)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(197) Genomic(2) cDNA(188) Primer pair(5) Other(2) Antibodies(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000007872
DoTS DT.101304621, DT.101322980, DT.110841457, DT.110841477, DT.110842041, DT.55123207, DT.99858479
Consensus CDS Project CCDS18800.1
UniGene 110
DFCI TC1574082, TC1582478
NIA Mouse Gene Index U004959
Entrez Gene 15903
VEGA Gene Model OTTMUSG00000009864
International Mouse Knockout Project Status Id3
Protein
domains
InterPro ID Description
IPR001092 Helix-loop-helix DNA-binding domain
IPR011598 Helix-loop-helix DNA-binding
Graphical View of Protein Domain Structure
References
(Earliest) J:13202 Christy BA et al., "An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene." Proc Natl Acad Sci U S A 1991 Mar 1;88(5):1815-9
(Latest) J:155785 Brinkmeier ML et al., "Discovery of transcriptional regulators and signaling pathways in the developing pituitary gland by bioinformatic and genomic approaches." Genomics 2009 May;93(5):449-60
All references(80)
Other
accession IDs 		MGD-MRK-11155
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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