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| Nomenclature |
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Symbol:
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Rr20tm1.1Vlcg
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Name:
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regulatory region 20;
targeted mutation 1.1, Velocigene
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MGI ID: |
MGI:5441845 |
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Synonyms: |
ECR5- |
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Gene:
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Rr20
Location:
unknown
Genetic Position: Chr11,
Syntenic
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:188586
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Parent Cell Line:
| F1H4 (ES Cell) |
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Strain of Origin:
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(129S6/SvEvTac x C57BL/6NTac)F1
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intergenic deletion |
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Mutation details: The evolutionarily conserved candidate enhancer element (ECR5) that acts as a distal enhancer to Sost was replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. Immunohistochemistry confirmed highly variable expression of Sost. (J:188586)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Rr20 Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:188586
Collette NM et al.,
"Targeted deletion of Sost distal enhancer increases bone formation and bone mass."
Proc Natl Acad Sci U S A 2012 Aug 28;109(35):14092-7
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All: |
1 reference(s)
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Analysis Tools
