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| Nomenclature |
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Symbol:
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Shank2tm1Mgle
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Name:
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SH3/ankyrin domain gene 2;
targeted mutation 1, Min Goo Lee
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MGI ID: |
MGI:5437479 |
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Gene:
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Shank2
Location:
Chr7:144001928-144424494 bp, + strand
Genetic Position: Chr7,
88.45 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:186718
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: An approximately 3.1 kb genomic fragment including exons 6 and 7 was replaced with a floxed neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in the brains of homozygous mice. (J:186718)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Shank2 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:186718
Won H et al.,
"Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function."
Nature 2012 Jun 14;486(7402):261-5
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All: |
1 reference(s)
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Analysis Tools
