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| Nomenclature |
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Symbol:
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Pink1tm1.1Wrst
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Name:
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PTEN induced putative kinase 1;
targeted mutation 1.1, Wolfgang Wurst
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MGI ID: |
MGI:5436308 |
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Synonyms: |
Pink1- |
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Gene:
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Pink1
Location:
Chr4:138313409-138326307 bp, - strand
Genetic Position: Chr4,
70.14 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:183290
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Parent Cell Line:
| TBV2 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A loxP site and FRt flanked neo cassette were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 3 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 2 and 3. RT-PCR analysis indicates a dramatic reduction in mRNA expression in homozygous mice. (J:183290)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pink1 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:183290
Glasl L et al.,
"Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb."
Exp Neurol 2012 May;235(1):214-27
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All: |
1 reference(s)
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Analysis Tools
