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| Nomenclature |
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Symbol:
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Tcf7l2tm2.1Cle
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Name:
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transcription factor 7 like 2, T cell specific, HMG box;
targeted mutation 2.1, Hans Clever
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MGI ID: |
MGI:5430317 |
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Synonyms: |
Tcf4LoxP |
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Gene:
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Tcf7l2
Location:
Chr19:55741820-55933654 bp, + strand
Genetic Position: Chr19,
51.59 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:185753
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Parent Cell Line:
| IB10/E14IB10 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: An FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 11. An additional loxP site was inserted downstream of exon 11. Flp-mediated recombination removed the neo cassette and left exon 11 floxed. (J:185753)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tcf7l2 Mutation:
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17 strains or lines available |
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| References |
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Original: |
J:185753
van Es JH et al.,
"A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal."
Mol Cell Biol 2012 May;32(10):1918-27
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All: |
1 reference(s)
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Analysis Tools
