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| Nomenclature |
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Symbol:
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Tg(HLA-DR2)#Lfug
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Name:
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transgene insertion, Lars Fugger
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MGI ID: |
MGI:5429698 |
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Synonyms: |
DR2, HLA-DR2 |
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Transgene:
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Tg(HLA-DR2)#Lfug
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(DBA/2 x C57BL/6)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The murine MHC class II gene Ea promoter drives expression of the human HLA-DRA*0101 and HLA-DRB1*1501 DNAs. The HLA-DRA*0101 and HLA-DRB1*1501 are MS susceptibility genes found in individuals of European descent. (J:134764)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:134764
Madsen LS et al.,
"A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor."
Nat Genet 1999 Nov;23(3):343-7
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All: |
1 reference(s)
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Analysis Tools
