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| Nomenclature |
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Symbol:
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Apoetm3(APOE_i4)Yhg
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Name:
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apolipoprotein E;
targeted mutation 3, Yadong Huang
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MGI ID: |
MGI:5427463 |
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Synonyms: |
ApoE4-fKI, E4+ |
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Gene:
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Apoe
Location:
Chr7:19696109-19699166 bp, - strand
Genetic Position: Chr7,
9.94 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:184138
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The coding sequence (exons 2 through 4) was replaced with the corresponding human genomic sequence encoding isoform 4. A loxP site was inserted 5' of the human sequence and a neo cassette with a 5' loxP site was inserted downstream of the human sequence. (J:184138)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Apoe Mutation:
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55 strains or lines available |
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| References |
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Original: |
J:184138
Bien-Ly N et al.,
"Reducing human apolipoprotein E levels attenuates age-dependent Abeta accumulation in mutant human amyloid precursor protein transgenic mice."
J Neurosci 2012 Apr 4;32(14):4803-11
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All: |
1 reference(s)
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Analysis Tools
