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| Nomenclature |
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Symbol:
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Jak2tm1Mohi
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Name:
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Janus kinase 2;
targeted mutation 1, M Golam Mohi
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MGI ID: |
MGI:5320677 |
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Synonyms: |
Jak2V617F |
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Gene:
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Jak2
Location:
Chr19:29251828-29313080 bp, + strand
Genetic Position: Chr19,
23.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:184283
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: Exon 13 was replaced with a loxP site cDNA encoding exons 13 through 24, neo/STOP cassette, loxP site and modified exon 13 in which nucleotide substitutions result in the the amino acid substitution of phenylalanine for valine at position 617 (V617F). (J:184283)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Jak2 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:184283
Akada H et al.,
"Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease."
Blood 2010 Apr 29;115(17):3589-97
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All: |
2 reference(s)
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Analysis Tools
