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| Nomenclature |
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Symbol:
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Brca1tm1.1Jjon
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Name:
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breast cancer 1;
targeted mutation 1.1, Jos Jonkers
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MGI ID: |
MGI:5307254 |
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Synonyms: |
Brca1C61G |
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Gene:
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Brca1
Location:
Chr11:101488764-101551955 bp, - strand
Genetic Position: Chr11,
65.18 cM, cytoband D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:178595
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Single point mutation |
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Mutation details: A floxed neo cassette was inserted upstream of exon 5 and a T to G mutation, resulting in a cysteine to glycine substitution at amino acid position 61 in a conserved RING domain, was introduced via homologous recombination. Cre mediated recombination removed the neo cassette. (J:178595)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Brca1 Mutation:
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42 strains or lines available |
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| References |
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Original: |
J:178595
Drost R et al.,
"BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance."
Cancer Cell 2011 Dec 13;20(6):797-809
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All: |
1 reference(s)
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Analysis Tools
