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| Nomenclature |
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Symbol:
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Nkx2-2tm2.1Suss
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Name:
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NK2 transcription factor related, locus 2 (Drosophila);
targeted mutation 2.1, Lori Sussel
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MGI ID: |
MGI:5297810 |
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Synonyms: |
Nkx2.2TNmut |
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Gene:
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Nkx2-2
Location:
Chr2:147177546-147194243 bp, - strand
Genetic Position: Chr2,
72.63 cM, cytoband H
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:177838
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Parent Cell Line:
| TL1/TL-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: Recombination mediated cassette exchange (RMCE) into Nkx2-2tm1Suss inserted nucleotide substitutions that result in several amino acid substitutions in the tinman (TN) domain (TGFSVKDILDLP to TGFAAAAIVDLP). An FRT-flanked neo cassette used for selection was removed by flp-mediated recombination. (J:177838)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Nkx2-2 Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:177838
Papizan JB et al.,
"Nkx2.2 repressor complex regulates islet beta-cell specification and prevents beta-to-alpha-cell reprogramming."
Genes Dev 2011 Nov 1;25(21):2291-305
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All: |
1 reference(s)
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Analysis Tools
