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| Nomenclature |
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Symbol:
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Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat
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Name:
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gene trap ROSA 26, Philippe Soriano;
targeted mutation 3, Spyros Artavanis-Tsakonas
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MGI ID: |
MGI:5007799 |
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Synonyms: |
Gt(ROSA)26Sortm1(NOTCH3*R1031C)Sat, NOTCH3R1031C |
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Gene:
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Gt(ROSA)26Sor
Location:
Chr6:113067428-113077333 bp, - strand
Genetic Position: Chr6,
52.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:171887
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Parent Cell Line:
| W4 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A targeting vector containing a splice acceptor site, a floxed PGK neomycin cassette, a human NOTCH3 cDNA with an R1031C mutation and an IRES-nuclear GFP sequence was inserted via homologous recombination. (J:171887)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:171887
Arboleda-Velasquez JF et al.,
"PNAS Plus: Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease."
Proc Natl Acad Sci U S A 2011 May 24;108(21):E128-35
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All: |
1 reference(s)
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Analysis Tools
