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| Nomenclature |
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Symbol:
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Tg(Mov1/Tyr)OVE876BPay
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Name:
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transgene insertion OVE876B, Richard Paylor
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MGI ID: |
MGI:5006860 |
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Synonyms: |
MALTT, multiple autistic-like trait transgenic |
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Transgene:
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Tg(Mov1/Tyr)OVE876BPay
Location:
unknown
Genetic Position: ChrX,
Syntenic
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: Sequences from the 5' end of the Moloney murine leukemia virus were linked to a tyrosinase minigene consisting of a 2.1-kb promoter linked to a 1.9-kb tyrosinase cDNA. Expression of the tyrosinase minigene leads to melanin synthesis in the skin and fur. The transgene inserted in the non-coding region between Gm732 and Brwd3 on chromosome X. PCR amplification with minigene-only primer sets suggests that at minimum 2 copies inserted in tandem, while Southern blot hybridization indicates a maximum of 4 copies inserted together. Expression of Fam46d, located near the site of transgenic intergration, is upregulated. (J:167614)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:167614
Hamilton SM et al.,
"Multiple autism-like behaviors in a novel transgenic mouse model."
Behav Brain Res 2011 Mar 17;218(1):29-41
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All: |
1 reference(s)
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Analysis Tools
