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| Nomenclature |
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Symbol:
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Boctm1Rsk
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Name:
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biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein;
targeted mutation 1, Robert S Krauss
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MGI ID: |
MGI:5000228 |
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Synonyms: |
Boc-, BocAP-1 |
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Gene:
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Boc
Location:
Chr16:44485049-44558897 bp, - strand
Genetic Position: Chr16,
28.81 cM, cytoband B5
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:171767
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 540 bp region including the entire first coding exon was deleted and an IRES-hAP and floxed PGK-neo cassette was inserted in exon 2 via homologous recombination. Western blot analysis confirmed the absence of protein expression in homozygous embryos. Alkaline phosphatase activity mirrors endogenous gene expression. (J:171767)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Boc Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:171767
Zhang W et al.,
"Boc modifies the holoprosencephaly spectrum of Cdo mutant mice."
Dis Model Mech 2011 May-Jun;4(3):368-80
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All: |
1 reference(s)
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Analysis Tools
