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| Nomenclature |
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Symbol:
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Shank3tm2Gfng
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Name:
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SH3/ankyrin domain gene 3;
targeted mutation 2, Guoping Feng
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MGI ID: |
MGI:4949738 |
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Synonyms: |
Shank3B- |
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Gene:
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Shank3
Location:
Chr15:89499623-89560261 bp, + strand
Genetic Position: Chr15,
44.96 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:171113
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (other) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The sequence from exons 13 through 16, which encode the PDZ domain, was replaced with a neo cassette. The absence of alpha and beta isoform expression and reduced gamma isoform expression were confirmed by western blot analysis on brain extracts. (J:171113)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:171113
Peca J et al.,
"Shank3 mutant mice display autistic-like behaviours and striatal dysfunction."
Nature 2011 Apr 28;472(7344):437-42
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All: |
2 reference(s)
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Analysis Tools
