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| Nomenclature |
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Symbol:
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Tg(Thy1-MAPT*)30Schd
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Name:
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transgene insertion 30, Katharina Schindowski
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MGI ID: |
MGI:4940070 |
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Synonyms: |
Tg30, THY-Tau30 |
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Transgene:
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Tg(Thy1-MAPT*)30Schd
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6 x CBA
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: cDNA of the 412-amino acid 4-repeat isoform of the human MAPT gene was reamplified and modified by PCR-based site directed mutagenesis to introduce a Kozak-sequence and the mutations G272V and P301S (numbering according to longest human isoform). The cDNA was inserted into a Thy1.2 expression vector and the construct was microinjected into a C57BL/6 x CBA background. 5-10 copies of the transgene are present in this line. Line 30 animals display high levels of human tau in the spinal cord. In the brain, high tau protein levels are observed in the hippocampus with low levels found in the cortex.
(J:111982)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:111982
Schindowski K et al.,
"Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits."
Am J Pathol 2006 Aug;169(2):599-616
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All: |
2 reference(s)
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Analysis Tools
