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| Nomenclature |
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Symbol:
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Sh2d1b1/Sh2d1b2tm1.1Cpt
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Name:
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SH2 domain protein 1B1;
targeted mutation 1.1, Cox Terhorst
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MGI ID: |
MGI:4840395 |
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Synonyms: |
EAT-2A/B- |
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Gene:
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Sh2d1b1
Location:
Chr1:170277376-170285662 bp, + strand
Genetic Position: Chr1,
76.84 cM, cytoband H2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:166054
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Parent Cell Line:
| Bruce 4 (ES Cell) |
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Strain of Origin:
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B6.Cg-Thy1a
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intergenic deletion |
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Mutation details: Exon 1 of Sh2d1b1 was replaced with a floxed neo cassette while exon 1 of Sh2d1b2 was replaced with a hygro cassette with a 5' loxP site. Cre mediated recombination removed the intervening sequence. (J:166054)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Sh2d1b1 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:166054
Wang N et al.,
"Cutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse."
J Immunol 2010 Nov 15;185(10):5683-7
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All: |
2 reference(s)
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Analysis Tools
