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| Nomenclature |
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Symbol:
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Pip5k1ctm1.2Ref
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Name:
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phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma;
targeted mutation 1.2, Reinhard Fassler
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MGI ID: |
MGI:4838023 |
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Synonyms: |
PIPKIgamma90-, PIPKIgammadeltaE17 |
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Gene:
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Pip5k1c
Location:
Chr10:81292963-81319973 bp, + strand
Genetic Position: Chr10,
39.72 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:164732
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (other) |
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Mutation: | |
Intragenic deletion |
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Mutation details: A loxP site was inserted usptream of exon 17. An FRT-flanked neo cassette with a 3' loxP site was isnserted downstream of exon 17. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed the neo cassette. The absence of protein expression was confirmed by western blot analysis on T cell extracts. (J:180016)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pip5k1c Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:164732
Wernimont SA et al.,
"PIPKI gamma 90 negatively regulates LFA-1-mediated adhesion and activation in antigen-induced CD4+ T cells."
J Immunol 2010 Oct 15;185(8):4714-23
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All: |
2 reference(s)
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Analysis Tools
