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| Nomenclature |
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Symbol:
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Myh6tm3.1Jse
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Name:
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myosin, heavy polypeptide 6, cardiac muscle, alpha;
targeted mutation 3.1, Jonathan G Seidman
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MGI ID: |
MGI:4837367 |
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Synonyms: |
alpha-MHC719 |
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Gene:
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Myh6
Location:
Chr14:54952246-54966927 bp, - strand
Genetic Position: Chr14,
28.01 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:165269
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: Exon 19 was replaced with a modified one containing nucleotide substitutions that result the amino acid substitution of arginine with tryphtophan at position 719 (R719W). A floxed neo cassette inserted downstream of exon 19 was removed by cre mediated recombination. (J:165269)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Myh6 Mutation:
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72 strains or lines available |
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| References |
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Original: |
J:165269
Teekakirikul P et al.,
"Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-beta."
J Clin Invest 2010 Oct 1;120(10):3520-9
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All: |
1 reference(s)
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Analysis Tools
