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| Nomenclature |
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Symbol:
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Mdm2tm1.1Ypz
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Name:
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transformed mouse 3T3 cell double minute 2;
targeted mutation 1.1, Yangping Zhang
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MGI ID: |
MGI:4836988 |
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Synonyms: |
Mdm2C305F |
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Gene:
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Mdm2
Location:
Chr10:117688888-117710758 bp, - strand
Genetic Position: Chr10,
66.32 cM, cytoband C1-C3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:164200
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: Site-directed mutagenesis converted the TGT codon to TTT resulting in the amino acid substitution of phenylalanine for cysteine at position 305 (C305F). Additional codons were modified to introduce an SpeI site. A floxed neo cassette was removed by cre mediated recombination. The amino acid substitution disrupts binding to Smr3a (RPL5) and RPL11. (J:164200)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mdm2 Mutation:
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30 strains or lines available |
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| References |
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Original: |
J:164200
Macias E et al.,
"An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction."
Cancer Cell 2010 Sep 14;18(3):231-43
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All: |
2 reference(s)
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Analysis Tools
