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| Nomenclature |
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Symbol:
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Hspa4tm1.1Miv
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Name:
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heat shock protein 4;
targeted mutation 1.1, Nahid F Mivechi
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MGI ID: |
MGI:4836945 |
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Synonyms: |
hsp110- |
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Gene:
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Hspa4
Location:
Chr11:53259814-53300457 bp, - strand
Genetic Position: Chr11,
31.91 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:164904
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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C57BL/6
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 1 was replaced with a lacZ gene and floxed neo cassette. Cre mediated recombination removed the neo cassette. The absence of full length product and production of beta-galactosidase was confirmed by western blot analysis of brain extracts. (J:164904)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Hspa4 Mutation:
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45 strains or lines available |
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| References |
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Original: |
J:164904
Eroglu B et al.,
"Loss of Hsp110 leads to age-dependent tau hyperphosphorylation and early accumulation of insoluble amyloid beta."
Mol Cell Biol 2010 Oct;30(19):4626-43
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All: |
1 reference(s)
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Analysis Tools
