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| Nomenclature |
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Symbol:
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Del(7Slx1b-Sept1)4Aam
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Name:
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deletion, Chr 7, Alea A Mills 4
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MGI ID: |
MGI:4462822 |
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Synonyms: |
16p11.2 df, Del(7)4Aam |
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Gene:
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Del(7Slx1b-Sept1)4Aam
Location:
unknown
Genetic Position: Chr7,
Syntenic
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:176335
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Parent Cell Line:
| AB2.2 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (other) |
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Mutations: | |
Insertion, Intergenic deletion |
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Mutation details: Chromosome-engineering cassettes were inserted into mouse Chromosome 7, bracketing a span of approximately 0.39 Mb between the SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (Smg1) and the aldolase A, fructose-bisphosphate (Aldoa) loci. The cassette placed at the proximal locus contained Smg1, a puromycin resistance gene, a loxP site, a 3' portion of an hprt minigene and an agouti transgene. The cassette placed at the distal locus contained the Aldoa gene, a tyrosinase minigene, a 5' portion of an hprt minigene, a loxP site and neomycin resistance gene. Double-targeted ES cells were subjected to transient cre recombinase expression with subsequent selection of recombinants by using hypoxanthine aminopterin thymidine (HAT) media to delete the targeted region. (J:176335)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:176335
Horev G et al.,
"Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism."
Proc Natl Acad Sci U S A 2011 Oct 3;():
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All: |
1 reference(s)
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Analysis Tools
